Hydrodynamic trap for single particles and cells

Melikhan Tanyeri; Eric M. Johnson-Chavarria; Charles M. Schroeder

doi:10.1063/1.3431664

Hydrodynamic trap for single particles and cells

Melikhan Tanyeri, Eric M. Johnson-Chavarria, Charles M. Schroeder

Research output: Contribution to journal › Article › peer-review

Abstract

Trapping and manipulation of microscale and nanoscale particles is demonstrated using the sole action of hydrodynamic forces. We developed an automated particle trap based on a stagnation point flow generated in a microfluidic device. The hydrodynamic trap enables confinement and manipulation of single particles in low viscosity (1-10 cP) aqueous solution. Using this method, we trapped microscale and nanoscale particles (100 nm-15 μm) for long time scales (minutes to hours). We demonstrate particle confinement to within 1 μm of the trap center, corresponding to a trap stiffness of ∼ 10 ^-5 - 10^-4 pN/nm.

Original language	English (US)
Article number	224101
Journal	Applied Physics Letters
Volume	96
Issue number	22
DOIs	https://doi.org/10.1063/1.3431664
State	Published - May 31 2010

ASJC Scopus subject areas

Physics and Astronomy (miscellaneous)

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title = "Hydrodynamic trap for single particles and cells",

abstract = "Trapping and manipulation of microscale and nanoscale particles is demonstrated using the sole action of hydrodynamic forces. We developed an automated particle trap based on a stagnation point flow generated in a microfluidic device. The hydrodynamic trap enables confinement and manipulation of single particles in low viscosity (1-10 cP) aqueous solution. Using this method, we trapped microscale and nanoscale particles (100 nm-15 μm) for long time scales (minutes to hours). We demonstrate particle confinement to within 1 μm of the trap center, corresponding to a trap stiffness of ∼ 10 -5 - 10-4 pN/nm.",

author = "Melikhan Tanyeri and Johnson-Chavarria, {Eric M.} and Schroeder, {Charles M.}",

note = "Funding Information: This work was funded by an NIH Pathway to Independence (PI) Award, under Grant No. 4R00HG004183-03. ",

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AU - Schroeder, Charles M.

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N2 - Trapping and manipulation of microscale and nanoscale particles is demonstrated using the sole action of hydrodynamic forces. We developed an automated particle trap based on a stagnation point flow generated in a microfluidic device. The hydrodynamic trap enables confinement and manipulation of single particles in low viscosity (1-10 cP) aqueous solution. Using this method, we trapped microscale and nanoscale particles (100 nm-15 μm) for long time scales (minutes to hours). We demonstrate particle confinement to within 1 μm of the trap center, corresponding to a trap stiffness of ∼ 10 -5 - 10-4 pN/nm.

AB - Trapping and manipulation of microscale and nanoscale particles is demonstrated using the sole action of hydrodynamic forces. We developed an automated particle trap based on a stagnation point flow generated in a microfluidic device. The hydrodynamic trap enables confinement and manipulation of single particles in low viscosity (1-10 cP) aqueous solution. Using this method, we trapped microscale and nanoscale particles (100 nm-15 μm) for long time scales (minutes to hours). We demonstrate particle confinement to within 1 μm of the trap center, corresponding to a trap stiffness of ∼ 10 -5 - 10-4 pN/nm.

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Hydrodynamic trap for single particles and cells

Abstract

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