Hybrid Amphotericin B derivatives with reduced toxicity

Martin D. Burke (Inventor), Anuj Khandelwal (Inventor), Jiabao Zhang (Inventor), Anna SantaMaria (Inventor)

Research output: Patent

Abstract

Disclosed are derivatives of amphotericin B (AmB) characterized by improved clinical efficacy with reduced toxicity compared to AmB. Also disclosed are pharmaceutical compositions comprising the AmB derivatives, therapeutic methods of using the AmB derivatives and methods of making the AmB derivatives.
Original languageEnglish (US)
U.S. patent number11198705
StatePublished - Dec 14 2021

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