Human single-chain T cell receptors

David M Kranz (Inventor), David Henry Aggen (Inventor)

Research output: Patent


A soluble human single-chain T cell receptor (TCR) having the structure: Vα2-L-Vβ or Vβ-L-Vα2, wherein L is a linker peptide that links Vβ with Vα, Vβ is a TCR variable β region, and Vα2 is a TCR variable α region of the family 2 is provided. The provided scTCR is useful for many purposes, including the treatment of cancer, viral diseases and autoimmune diseases.
Original languageEnglish (US)
U.S. patent number10464987
Filing date10/6/10
StatePublished - Nov 5 2019


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