Human single-chain T cell receptors

David M Kranz; David Henry Aggen

Human single-chain T cell receptors

David M Kranz (Inventor), David Henry Aggen (Inventor)

Research output: Patent

Abstract

A soluble human single-chain T cell receptor (TCR) having the structure: Vα2-L-Vβ or Vβ-L-Vα2, wherein L is a linker peptide that links Vβ with Vα, Vβ is a TCR variable β region, and Vα2 is a TCR variable α region of the family 2 is provided. The provided scTCR is useful for many purposes, including the treatment of cancer, viral diseases and autoimmune diseases.

Original language	English (US)
U.S. patent number	10464987
Filing date	10/6/10
State	Published - Nov 5 2019

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title = "Human single-chain T cell receptors",

abstract = "A soluble human single-chain T cell receptor (TCR) having the structure: Vα2-L-Vβ or Vβ-L-Vα2, wherein L is a linker peptide that links Vβ with Vα, Vβ is a TCR variable β region, and Vα2 is a TCR variable α region of the family 2 is provided. The provided scTCR is useful for many purposes, including the treatment of cancer, viral diseases and autoimmune diseases.",

author = "Kranz, {David M} and Aggen, {David Henry}",

note = "This invention was made with U.S. Government support under Grant number R01 GM55767 awarded by the National Institutes of Health. The U.S. Government has certain rights in the invention.; 10464987",

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language = "English (US)",

type = "Patent",

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TY - PAT

T1 - Human single-chain T cell receptors

AU - Kranz, David M

AU - Aggen, David Henry

N1 - This invention was made with U.S. Government support under Grant number R01 GM55767 awarded by the National Institutes of Health. The U.S. Government has certain rights in the invention.

PY - 2019/11/5

Y1 - 2019/11/5

N2 - A soluble human single-chain T cell receptor (TCR) having the structure: Vα2-L-Vβ or Vβ-L-Vα2, wherein L is a linker peptide that links Vβ with Vα, Vβ is a TCR variable β region, and Vα2 is a TCR variable α region of the family 2 is provided. The provided scTCR is useful for many purposes, including the treatment of cancer, viral diseases and autoimmune diseases.

AB - A soluble human single-chain T cell receptor (TCR) having the structure: Vα2-L-Vβ or Vβ-L-Vα2, wherein L is a linker peptide that links Vβ with Vα, Vβ is a TCR variable β region, and Vα2 is a TCR variable α region of the family 2 is provided. The provided scTCR is useful for many purposes, including the treatment of cancer, viral diseases and autoimmune diseases.

M3 - Patent

M1 - 10464987

Y2 - 2010/10/06

ER -

Human single-chain T cell receptors

Abstract

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