Human estrogen receptor mutants with altered estrogen and antiestrogen ligand discrimination

Keyphrases

• 4-hydroxytamoxifen 10%
• Amino Acids 30%
• Antiestrogen 100%
• Aziridine 20%
• Basic Functional Groups 10%
• Binding Activity 10%
• Binding Affinity 20%
• Binding Site 10%
• Charged Amino Acids 20%
• Chinese Hamster Ovary Cells 10%
• COS Cells 10%
• Covalent Labeling 10%
• Dissociation 10%
• Enhanced Sensitivity 10%
• Estradiol 10%
• Estrogen 100%
• Estrogen Receptor 30%
• Estrogen Response Element 20%
• Estrogen-responsive 10%
• Gel Retardation Assay 10%
• Hormone Binding 30%
• Ligand Discrimination 100%
• Ligand-binding Domain 10%
• Local Charge 10%
• Membrane Estrogen Receptor 100%
• Polar Amino Acids 20%
• Polar Functional Groups 10%
• Reporter Gene 20%
• Side Chain 20%
• Side Chain Interactions 10%
• Site-directed mutagenesis 10%
• Transactivation 20%
• Transcriptional Activation 10%

Biochemistry, Genetics and Molecular Biology

• Amino Acids 83%
• Binding Affinity 33%
• Binding Domain 16%
• Binding Site 16%
• Chinese Hamster 16%
• Electrophoretic Mobility-Shift Assay 16%
• Estradiol 16%
• Estrogen Receptor 100%
• Estrogen Responsive Element 33%
• Hormone Binding 50%
• Reporter Gene 33%
• Site-Directed Mutagenesis 16%
• Transactivation 50%
• Transcription 50%
• Transcription Initiation 16%
• Wild Type 50%

Pharmacology, Toxicology and Pharmaceutical Science

• Afimoxifene 10%
• Amino Acid 50%
• Antiestrogen 100%
• Aziridine 20%
• Binding Site 10%
• Chinese Hamster 10%
• Diethylstilbestrol 10%
• Estrogen Receptor 100%
• Functional Groups 10%
• Receptor 70%
• Site-Directed Mutagenesis 10%