Human chromosome 19 and related regions in mouse: Conservative and lineage-specific evolution

P. Dehal; P. Predki; A. S. Olsen; A. Kobayashi; P. Folta; S. Lucas; M. Land; A. Terry; C. L. Ecale Zhou; S. Rash; Q. Zhang; L. Gordon; J. Kim; C. Elkin; M. J. Pollard; P. Richardson; D. Rokhsar; E. Uberbacher; T. Hawkins; E. Branscomb; L. Stubbs

doi:10.1126/science.1060310

Human chromosome 19 and related regions in mouse: Conservative and lineage-specific evolution

P. Dehal, P. Predki, A. S. Olsen, A. Kobayashi, P. Folta, S. Lucas, M. Land, A. Terry, C. L. Ecale Zhou, S. Rash, Q. Zhang, L. Gordon, J. Kim, C. Elkin, M. J. Pollard, P. Richardson, D. Rokhsar, E. Uberbacher, T. Hawkins, E. BranscombL. Stubbs

Research output: Contribution to journal › Article › peer-review

Abstract

To illuminate the function and evolutionary history of both genomes, we sequenced mouse DNA related to human chromosome 19. Comparative sequence alignments yielded confirmatory evidence for hypothetical genes and identified exons, regulatory elements, and candidate genes that were missed by other predictive methods. Chromosome-wide comparisons revealed a difference between single-copy HSA19 genes, which are overwhelmingly conserved in mouse, and genes residing in tandem familial clusters, which differ extensively in number, coding capacity, and organization between the two species. Finally, we sequenced breakpoints of all 15 evolutionary rearrangements, providing a view of the forces that drive chromosome evolution in mammals.

Original language	English (US)
Pages (from-to)	104-111
Number of pages	8
Journal	Science
Volume	293
Issue number	5527
DOIs	https://doi.org/10.1126/science.1060310
State	Published - Jul 6 2001
Externally published	Yes

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Dehal, P., Predki, P., Olsen, A. S., Kobayashi, A., Folta, P., Lucas, S., Land, M., Terry, A., Ecale Zhou, C. L., Rash, S., Zhang, Q., Gordon, L., Kim, J., Elkin, C., Pollard, M. J., Richardson, P., Rokhsar, D., Uberbacher, E., Hawkins, T., ... Stubbs, L. (2001). Human chromosome 19 and related regions in mouse: Conservative and lineage-specific evolution. Science, 293(5527), 104-111. https://doi.org/10.1126/science.1060310

Dehal, P, Predki, P, Olsen, AS, Kobayashi, A, Folta, P, Lucas, S, Land, M, Terry, A, Ecale Zhou, CL, Rash, S, Zhang, Q, Gordon, L, Kim, J, Elkin, C, Pollard, MJ, Richardson, P, Rokhsar, D, Uberbacher, E, Hawkins, T, Branscomb, E & Stubbs, L 2001, 'Human chromosome 19 and related regions in mouse: Conservative and lineage-specific evolution', Science, vol. 293, no. 5527, pp. 104-111. https://doi.org/10.1126/science.1060310

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title = "Human chromosome 19 and related regions in mouse: Conservative and lineage-specific evolution",

abstract = "To illuminate the function and evolutionary history of both genomes, we sequenced mouse DNA related to human chromosome 19. Comparative sequence alignments yielded confirmatory evidence for hypothetical genes and identified exons, regulatory elements, and candidate genes that were missed by other predictive methods. Chromosome-wide comparisons revealed a difference between single-copy HSA19 genes, which are overwhelmingly conserved in mouse, and genes residing in tandem familial clusters, which differ extensively in number, coding capacity, and organization between the two species. Finally, we sequenced breakpoints of all 15 evolutionary rearrangements, providing a view of the forces that drive chromosome evolution in mammals.",

author = "P. Dehal and P. Predki and Olsen, {A. S.} and A. Kobayashi and P. Folta and S. Lucas and M. Land and A. Terry and {Ecale Zhou}, {C. L.} and S. Rash and Q. Zhang and L. Gordon and J. Kim and C. Elkin and Pollard, {M. J.} and P. Richardson and D. Rokhsar and E. Uberbacher and T. Hawkins and E. Branscomb and L. Stubbs",

year = "2001",

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doi = "10.1126/science.1060310",

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AU - Dehal, P.

AU - Predki, P.

AU - Olsen, A. S.

AU - Kobayashi, A.

AU - Folta, P.

AU - Lucas, S.

AU - Land, M.

AU - Terry, A.

AU - Ecale Zhou, C. L.

AU - Rash, S.

AU - Zhang, Q.

AU - Gordon, L.

AU - Kim, J.

AU - Elkin, C.

AU - Pollard, M. J.

AU - Richardson, P.

AU - Rokhsar, D.

AU - Uberbacher, E.

AU - Hawkins, T.

AU - Branscomb, E.

AU - Stubbs, L.

PY - 2001/7/6

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N2 - To illuminate the function and evolutionary history of both genomes, we sequenced mouse DNA related to human chromosome 19. Comparative sequence alignments yielded confirmatory evidence for hypothetical genes and identified exons, regulatory elements, and candidate genes that were missed by other predictive methods. Chromosome-wide comparisons revealed a difference between single-copy HSA19 genes, which are overwhelmingly conserved in mouse, and genes residing in tandem familial clusters, which differ extensively in number, coding capacity, and organization between the two species. Finally, we sequenced breakpoints of all 15 evolutionary rearrangements, providing a view of the forces that drive chromosome evolution in mammals.

AB - To illuminate the function and evolutionary history of both genomes, we sequenced mouse DNA related to human chromosome 19. Comparative sequence alignments yielded confirmatory evidence for hypothetical genes and identified exons, regulatory elements, and candidate genes that were missed by other predictive methods. Chromosome-wide comparisons revealed a difference between single-copy HSA19 genes, which are overwhelmingly conserved in mouse, and genes residing in tandem familial clusters, which differ extensively in number, coding capacity, and organization between the two species. Finally, we sequenced breakpoints of all 15 evolutionary rearrangements, providing a view of the forces that drive chromosome evolution in mammals.

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Human chromosome 19 and related regions in mouse: Conservative and lineage-specific evolution

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