How to stabilize phospholipid liposomes (Using nanoparticles)

Liangfang Zhang, Steve Granick

Research output: Contribution to journalReview articlepeer-review


The simple strategy of mixing phospholipid liposomes with charged nanoparticles and using sonication to mix them at low volume fraction produces particle-stabilized liposomes that repel one another and do not fuse. Subsequently, the volume fraction can be raised as high as ≈50%, reversibly, still without fusion. In studies of liposome longevity, we verified the stability of particle-stabilized liposome suspensions with volume fraction up to 16% for up to 50 days, the longest period investigated. Fluorescent dyes were encapsulated within the particle-stabilized liposomes, without leakage. Although these particle-stabilized liposomes were stable against fusion, ≈75% of the outer liposome surface remained unoccupied. This opens the door to using particle-stabilized liposomes in various applications.

Original languageEnglish (US)
Pages (from-to)694-698
Number of pages5
JournalNano letters
Issue number4
StatePublished - Apr 2006

ASJC Scopus subject areas

  • Bioengineering
  • Chemistry(all)
  • Materials Science(all)
  • Condensed Matter Physics
  • Mechanical Engineering


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