Hormone-PAMAM dendrimer conjugates: Polymer dynamics and tether structure affect ligand access to receptors

Research output: Contribution to journalArticlepeer-review

Abstract

(Figure Presented) An open and closed case: Estradiol was conjugated to a PAMAM dendrimer (gray circle) through a short (17α-phenylethynyl) or a long (hexaethyleneglycol) tether to evaluate how ligand access to a receptor is affected. With the short tether (a), the hormone is free and solvent exposed, with unimpeded access to the estrogen receptor, while the long tether (b) wraps around the hormone and the dendrimer and markedly reduces access to the receptor.

Original languageEnglish (US)
Pages (from-to)7243-7248
Number of pages6
JournalAngewandte Chemie - International Edition
Volume45
Issue number43
DOIs
StatePublished - Nov 3 2006

Keywords

  • Dendrimers
  • Estrogen
  • Hormones
  • Receptors
  • Solvent effects

ASJC Scopus subject areas

  • Catalysis
  • Chemistry(all)

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