HMR-I is an origin of replication and a silencer in Saccharomyces cerevisiae

David H. Rivier, Joanne L. Ekena, Jasper Rine

Research output: Contribution to journalArticlepeer-review

Abstract

There appear to be fundamental differences between the properties of the silencers at HML and HMR, with some being origins of replication and others not. Moreover, past studies have suggested that HMR-I's role in silencing may be restricted to plasmid contexts. This study established that HMR-I, like HMR-E and unlike either HML silencer, is an origin of replication. Moreover, both HMR-E and HMR-I contribute to silencing of a chromosomal HMR locus. In addition, we found that Abf1p plays no unique role in silencer function.

Original languageEnglish (US)
Pages (from-to)521-529
Number of pages9
JournalGenetics
Volume151
Issue number2
StatePublished - Feb 1999

ASJC Scopus subject areas

  • Genetics

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