Histopathological and immunohistochemical findings of primary and metastatic medullary thyroid carcinoma in a young dog

Pablo Pin&tild;eyro, Miranda D. Vieson, Jose´ A. Ramos-Vara, Martha Moon-Larson, Geoffrey Saunders

Research output: Contribution to journalArticlepeer-review

Abstract

This report describes the gross, histological, and immunohistochemical features of medullary thyroid carcinoma (MTC) with pulmonary metastases in a young dog. Sheets of pleomorphic cells supported by fibrous stroma characterized the primary mass, while metastatic nodules had a neuroendocrine pattern. Despite differing histologic features, all masses showed marked immunoreactivity against calcitonin and multiple neuroendocrine markers consistent with MTC. Although MTC is a well-recognized entity, it may be difficult to distinguish this mass from other thyroid neoplasms, necessitating immunohistochemical characterization.

Original languageEnglish (US)
Pages (from-to)449-453
Number of pages5
JournalJournal of Veterinary Science
Volume15
Issue number3
DOIs
StatePublished - 2014
Externally publishedYes

Keywords

  • Calcitonin
  • Histopathology
  • Immunohistochemistry
  • Medullary thyroid carcinoma

ASJC Scopus subject areas

  • veterinary(all)

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