Histologic types and hormone receptors in breast cancer in men: a population-based study in 282 United States men

Helge Stalsberg, David B. Thomas, Karin A. Rosenblatt, L. Margarita Jimenez, Anne McTiernan, Annette Stemhagen, W. Douglas Thompson, Mary G. McCrea Curnen, William Satariano, Donald F. Austin, Raymond S. Greenberg, Charles Key, Laurence Kolonel, Dee West

Research output: Contribution to journalArticlepeer-review

Abstract

Histologic slides from 282 incident cases of breast cancer in men, that were identified in 10 population-based cancer registries in the United States, were reviewed by a single pathologist. Breast cancer more often presented in the noninvasive stage in men (10.8 percent of all cases) than would be expected among women. All noninvasive carcinomas were of the ductal type. Of invasive carcinomas, compared with women, men had smaller proportions of lobular and mucinous types and larger proportions of ductal and papillary types and Paget's disease. No case of tubular or medullary carcinoma was seen. The breast in men is composed only of ducts and normally contains no lobules, and the histologic types of breast carcinomas that predominate in men are likely of ductal origin. Estrogen and progesterone receptors were present in 86.7 percent and 76.3 percent of invasive carcinomas, respectively, which are higher proportions than would be expected among women. Also, unlike findings in women, receptor content was not associated with patient age at diagnosis.

Original languageEnglish (US)
Pages (from-to)143-151
Number of pages9
JournalCancer Causes and Control
Volume4
Issue number2
DOIs
StatePublished - Mar 1993
Externally publishedYes

Keywords

  • Breast cancer
  • United States
  • breast pathology
  • histologic classification
  • hormone receptors
  • males

ASJC Scopus subject areas

  • Oncology
  • Cancer Research

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