Histologic assessment and grading of the exocrine pancreas in the dog

S. J. Newman, J. M. Steiner, K. Woosley, D. A. Williams, L. Barton

Research output: Contribution to journalArticlepeer-review

Abstract

Histologic grading schemes for canine inflammatory conditions are sparse, and in the case of the canine pancreas, have not been previously described. In a previous study, we determined that histologic lesions of the exocrine pancreas occurred much more frequently than gross lesions. The intention of the current study was to develop a histologic grading scheme for nonneoplastic lesions following extensive assessment of the exocrine pancreas from dogs presented for necropsy examination. The parameters of the proposed scheme include neutrophilic inflammation, lymphocytic inflammation, pancreatic necrosis, pancreatic fat necrosis, edema, fibrosis, atrophy, and hyperplastic nodules. In this case series, the most common lesion was pancreatic hyperplastic nodules (80.2%), followed by lymphocytic inflammation (52.5%), fibrosis (49.5%), atrophy (46.5%), neutrophilic inflammation (31.7%), pancreatic fat necrosis (25.7%), pancreatic necrosis (16.8%), and edema (9.9%). Only 8 of the 101 animals had no evidence of any of the lesions in any of the sections examined. Fibrosis, atrophy, and/or lymphocytic infiltration most commonly accompanied nodules. Neutrophilic inflammation, when present, was often associated with necrosis (pancreatic necrosis, pancreatic fat necrosis, or both) and occasionally with hyperplastic nodules. The utilization of a grading scheme for exocrine pancreatic lesions will be useful in advancing the classification of exocrine pancreatic disease in the dog, which may lead to multicenter studies of exocrine pancreatic disorders in the dog and in other species.

Original languageEnglish (US)
Pages (from-to)115-118
Number of pages4
JournalJournal of Veterinary Diagnostic Investigation
Volume18
Issue number1
DOIs
StatePublished - Jan 2006
Externally publishedYes

Keywords

  • Canine
  • Hyperplasia
  • Inflammation
  • Pancreas
  • Pancreatitis

ASJC Scopus subject areas

  • General Veterinary

Fingerprint

Dive into the research topics of 'Histologic assessment and grading of the exocrine pancreas in the dog'. Together they form a unique fingerprint.

Cite this