Histochemical specificity of cholinesterases to phenylthioacetate in differentiated neural tissues of insects and teleosts

Gary M. Booth, Gregory S. Whitt

Research output: Contribution to journalArticle

Abstract

Housefly brain cholinesterase was histochemically demonstrated to hydrolyse phenylthioacetate at a very high rate, similar in distribution to that previously reported for acetylthiocholine. However, teleost neural retina cholinesterase would not hydrolyse the aromatic substrate, but the enzyme did cleave acetylthiocholine. Paraoxon and eserine were utilized to show selective patterns of inhibition in the two tissues. This high degree of substrate selectivity is discussed in conjunction with the possible development of selective insecticides.

Original languageEnglish (US)
Pages (from-to)521-528
Number of pages8
JournalTissue and Cell
Volume2
Issue number4
DOIs
StatePublished - Jan 1 1970

ASJC Scopus subject areas

  • Developmental Biology
  • Cell Biology

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