Hippocampal anatomy and water maze performance are affected by neonatal cryoanesthesia in rats of both sexes

Joseph L. Nuñez, Wendy A. Koss, Janice M. Juraska

Research output: Contribution to journalArticle

Abstract

There is recent evidence that cryoanesthesia, commonly used during neonatal hormone manipulations (e.g., gonadectomy), has deleterious effects on the morphology of the splenium of the corpus callosum and primary visual cortex in adult rats of both sexes. (Nunez and Juraska, 1998; Nunez, Kim, and Juraska, 1998). In the present study, the effect of neonatal cryoanesthesia on the morphology of the hippocampus and dentate gyrus and on performance in the Morris water maze was investigated. Cold exposure for as brief as 30 min (5°C) on Postnatal Day 1 resulted in a significant decrease in the volume of the hippocampus and in brain weight of adults. Performance on the water maze was also impaired in cold-exposed animals. This study indicates that not only morphology but also behavioral performance in adulthood are affected by neonatal cryoanesthesia. (C) 2000 Academic Press.

Original languageEnglish (US)
Pages (from-to)169-178
Number of pages10
JournalHormones and Behavior
Volume37
Issue number3
DOIs
StatePublished - May 2000

Keywords

  • Anesthesia
  • Dentate gyrus
  • Hypothermia
  • Spatial learning

ASJC Scopus subject areas

  • Endocrinology
  • Endocrine and Autonomic Systems
  • Behavioral Neuroscience

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