Highly variable patterns of linkage disequilibrium in multiple soybean populations

David L. Hyten, Ik Young Choi, Qijian Song, Randy C. Shoemaker, Randall L. Nelson, Jose M. Costa, James E. Specht, Perry B. Cregan

Research output: Contribution to journalArticle

Abstract

Prospects for utilizing whole-genome association analysis in autogamous plant populations appear promising due to the reported high levels of linkage disequilibrium (LD). To determine the optimal strategies for implementing association analysis in soybean (Glycine max L. Merr.), we analyzed the structure of LD in three regions of the genome varying in length from 336 to 574 kb. This analysis was conducted in four distinct groups of soybean germplasm: 26 accessions of the wild ancestor of soybean (Glycine soja Seib. et Zucc.); 52 Asian G. max Landraces, the immediate results of domestication from G. soja; 17 Asian Landrace introductions that became the ancestors of North American (N. Am.) cultivars, and 25 Elite Cultivars from N. Am. In G. soja, LD did not extend past 100 kb; however, in the three cultivated G. max groups, LD extended from 90 to 574 kb, likely due to the impacts of domestication and increased self-fertilization. The three genomic regions were highly variable relative to the extent of LD within the three cultivated soybean populations. G. soja appears to be ideal for fine mapping of genes, but due to the highly variable levels of LD in the Landraces and the Elite Cultivars, whole-genome association analysis in soybean may be more difficult than first anticipated.

Original languageEnglish (US)
Pages (from-to)1937-1944
Number of pages8
JournalGenetics
Volume175
Issue number4
DOIs
StatePublished - Apr 2007

ASJC Scopus subject areas

  • Genetics

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    Hyten, D. L., Choi, I. Y., Song, Q., Shoemaker, R. C., Nelson, R. L., Costa, J. M., Specht, J. E., & Cregan, P. B. (2007). Highly variable patterns of linkage disequilibrium in multiple soybean populations. Genetics, 175(4), 1937-1944. https://doi.org/10.1534/genetics.106.069740