TY - JOUR
T1 - Highly stretchable and customizable microneedle electrode arrays for intramuscular electromyography
AU - Zhao, Qinai
AU - Gribkova, Ekaterina
AU - Shen, Yiyang
AU - Cui, Jilai
AU - Naughton, Noel
AU - Liu, Liangshu
AU - Seo, Jaemin
AU - Tong, Baixin
AU - Gazzola, Mattia
AU - Gillette, Rhanor
AU - Zhao, Hangbo
N1 - Acknowledgments: We thank e. hwaun, h. luan, and P. G. Mehta for helpful discussions. this work made use of the John O\u2019Brien nanofabrication laboratory and the core center of excellence in nano imaging at the University of Southern california. Funding: this work was supported by Office of naval Research (OnR) Multidisciplinary University Research initiative n00014-19-1-2373. h.Z. acknowledges support from the Office of naval Research dURiP grant (n00014-21-1-2927). Q.Z., l.l., and J.S. acknowledge support from the USc viterbi School of engineering Graduate Fellowship. Author contributions: Q.Z. and h.Z. conceived the concept and designed the research. Q.Z., Y.S., J.S., and B.t. performed device fabrication and characterization. e.G., J.c., Q.Z., n.n., and R.G. performed ex vivo studies. l.l. performed finite element simulations. Q.Z., e.G., Y.S., J.c., n.n., l.l., M.G., R.G., and h.Z. analyzed the data. Q.Z. and h.Z. wrote the paper, with input from all co-authors. Competing interests: h.Z. and Q.Z. are inventors on two provisional patent applications filed by the University of Southern california (serial no. 63/468,959 and serial no. 63/469,024, filed 25 May 2023). the authors declare that they have no other competing interests. Data and materials availability: All data needed to evaluate the conclusions in the paper are present in the paper and/or the Supplementary Materials.
PY - 2024/5
Y1 - 2024/5
N2 - Stretchable three-dimensional (3D) penetrating microelectrode arrays have potential utility in various fields, including neuroscience, tissue engineering, and wearable bioelectronics. These 3D microelectrode arrays can penetrate and conform to dynamically deforming tissues, thereby facilitating targeted sensing and stimulation of interior regions in a minimally invasive manner. However, fabricating custom stretchable 3D microelectrode arrays presents material integration and patterning challenges. In this study, we present the design, fabrication, and applications of stretchable microneedle electrode arrays (SMNEAs) for sensing local intramuscular electromyography signals ex vivo. We use a unique hybrid fabrication scheme based on laser micromachining, microfabrication, and transfer printing to enable scalable fabrication of individually addressable SMNEA with high device stretchability (60 to 90%). The electrode geometries and recording regions, impedance, array layout, and length distribution are highly customizable. We demonstrate the use of SMNEAs as bioelectronic interfaces in recording intramuscular electromyography from various muscle groups in the buccal mass of Aplysia.
AB - Stretchable three-dimensional (3D) penetrating microelectrode arrays have potential utility in various fields, including neuroscience, tissue engineering, and wearable bioelectronics. These 3D microelectrode arrays can penetrate and conform to dynamically deforming tissues, thereby facilitating targeted sensing and stimulation of interior regions in a minimally invasive manner. However, fabricating custom stretchable 3D microelectrode arrays presents material integration and patterning challenges. In this study, we present the design, fabrication, and applications of stretchable microneedle electrode arrays (SMNEAs) for sensing local intramuscular electromyography signals ex vivo. We use a unique hybrid fabrication scheme based on laser micromachining, microfabrication, and transfer printing to enable scalable fabrication of individually addressable SMNEA with high device stretchability (60 to 90%). The electrode geometries and recording regions, impedance, array layout, and length distribution are highly customizable. We demonstrate the use of SMNEAs as bioelectronic interfaces in recording intramuscular electromyography from various muscle groups in the buccal mass of Aplysia.
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U2 - 10.1126/sciadv.adn7202
DO - 10.1126/sciadv.adn7202
M3 - Article
C2 - 38691612
AN - SCOPUS:85192034386
SN - 2375-2548
VL - 10
JO - Science Advances
JF - Science Advances
IS - 18
M1 - adn7202
ER -