Highly stereospecific, palladium-catalyzed cross-coupling of alkenylsilanols

Scott E. Denmark, Daniel Wehrli

Research output: Contribution to journalArticlepeer-review


(Formula presented) Alkenylsilanols bearing methyl ((E)-1 and (Z)-1) or isopropyl ((E)-2 and (Z)-2)) substituents are converted to disubstituted alkenes by a palladium-(0)-catalyzed cross-coupling reaction with aryl or vinyl iodides in the presence of tetrabutylammonium fluoride or hydroxide. Yields and stereoselectivities are generally high, and the reaction is compatible with a wide range of functional groups.

Original languageEnglish (US)
Pages (from-to)565-568
Number of pages4
JournalOrganic Letters
Issue number4
StatePublished - Feb 24 2000

ASJC Scopus subject areas

  • Biochemistry
  • Physical and Theoretical Chemistry
  • Organic Chemistry


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