Highly sensitive surface-enhanced raman nano-probing for direct proteomic profiling

Yi Chen, Zhida Xu, Logan Liu, Jean Philippe Coppe

Research output: Chapter in Book/Report/Conference proceedingConference contribution


Nanocone structures were fabricated by a unique etching-passivation process as the substrates for Surface Enhanced Raman Spectroscopy (SERS). This novel nanostructured SERS substrate allowed reaching unprecedented detection limits (fM of Rhodamin6G; pM of crude peptides), and supported the detection of subtle changes in peptide probe sequences, such as single amino acid phosphosphorylation or mutation. Thus, surface-conjugated peptides could be used as highly potent biological nano-sensors for sensitive profiling of specific protein-mediated chemical changes on nano-sensing probes. We hope such kinase-enzyme activity screening array device and technology will advance all aspects of Life Sciences, and potentially be applied to environment monitoring.

Original languageEnglish (US)
Title of host publicationIEEE Sensors 2010 Conference, SENSORS 2010
Number of pages4
StatePublished - 2010
Externally publishedYes
Event9th IEEE Sensors Conference 2010, SENSORS 2010 - Waikoloa, HI, United States
Duration: Nov 1 2010Nov 4 2010

Publication series

NameProceedings of IEEE Sensors


Other9th IEEE Sensors Conference 2010, SENSORS 2010
Country/TerritoryUnited States
CityWaikoloa, HI

ASJC Scopus subject areas

  • Electrical and Electronic Engineering


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