Highly regioselective catalytic oxidative coupling reactions: Synthetic and mechanistic investigations

Kami L. Hull, Erica L. Lanni, Melanie S. Sanford

Research output: Contribution to journalArticle

Abstract

A highly efficient and regioselective Pd-catalyzed method for the oxidative coupling of arylpyridine derivatives is reported. Remarkably, the reactions proceed at room temperature and are compatible with diverse functionalities, including aryl halides and thiophenes. Mechanistic studies suggest that these transformations proceed via a previously unprecedented mechanism involving two different pyridine-directed C-H activation reactions-one at a PdII center and one at PdIV.

Original languageEnglish (US)
Pages (from-to)14047-14049
Number of pages3
JournalJournal of the American Chemical Society
Volume128
Issue number43
DOIs
StatePublished - Nov 1 2006

ASJC Scopus subject areas

  • Catalysis
  • Chemistry(all)
  • Biochemistry
  • Colloid and Surface Chemistry

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