Highly non-linear contrast agent oscillations: The compression-only behavior

S. M. Van Der Meer, P. G. Marmottant, S. Hilgenfeldt, M. Versluis, D. Lohse, C. T. Chin, A. Bouakaz, F. Mastik, M. Emmer, N. De Jong

Research output: Chapter in Book/Report/Conference proceedingConference contribution


Here we report the observation of a highly non-linear bubble response of phospholipid coated contrast agents, termed 'compression-only behavior' where the microbubbles only compress, yet hardly expand. The occurrence of this phenomenon has been studied retrospectively and it was found that 33% of the examined cases show this behavior. The compression-only behavior is described by a newly developed shell model for phospholipid coated bubbles. The model extends previous elastic models with shell compressibility, a buckling radius and a break-up tension. It also predicts large amplitude oscillations, and bubble break-up.

Original languageEnglish (US)
Title of host publication2005 IEEE Ultrasonics Symposium
Number of pages3
StatePublished - Dec 1 2005
Externally publishedYes
Event2005 IEEE Ultrasonics Symposium - Rotterdam, Netherlands
Duration: Sep 18 2005Sep 21 2005

Publication series

NameProceedings - IEEE Ultrasonics Symposium
ISSN (Print)1051-0117


Other2005 IEEE Ultrasonics Symposium


  • Buckling model
  • Compression-only
  • Contrast agents

ASJC Scopus subject areas

  • Acoustics and Ultrasonics

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    Van Der Meer, S. M., Marmottant, P. G., Hilgenfeldt, S., Versluis, M., Lohse, D., Chin, C. T., Bouakaz, A., Mastik, F., Emmer, M., & De Jong, N. (2005). Highly non-linear contrast agent oscillations: The compression-only behavior. In 2005 IEEE Ultrasonics Symposium (pp. 974-976). [1603012] (Proceedings - IEEE Ultrasonics Symposium; Vol. 2). https://doi.org/10.1109/ULTSYM.2005.1603012