Highly efficient SiRNA delivery mediated by cationic helical polypeptides and polypeptide-based nanosystems

Lichen Yin, Nan Zheng, Jianjun Cheng

Research output: Chapter in Book/Report/Conference proceedingChapter

Abstract

RNA interference (RNAi) mediated by small interfering RNA (SiRNA) has recently emerged as a potent machinery in regulating gene expression at the post-translation step. Despite its efficiency and specificity, the biggest hurdle against its wide application is the safe and effective delivery of the SiRNA cargo into target cells. Here, we describe the highly effective SiRNA delivery mediated by the cationic helical polypeptides and polypeptide-based nanosystems both in vitro and in vivo via oral administration.

Original languageEnglish (US)
Title of host publicationMethods in Molecular Biology
PublisherHumana Press Inc.
Number of pages1
DOIs
StatePublished - Jan 1 2016

Publication series

NameMethods in Molecular Biology
Volume1364
ISSN (Print)1064-3745

Keywords

  • 47
  • Acute hepatic injury
  • Gene silencing
  • Helical polypeptide
  • Oral delivery
  • SiRNA delivery
  • Tumor necrosis factor α (TNF-α)

ASJC Scopus subject areas

  • Molecular Biology
  • Genetics

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