Highly active and stable DNAzyme-carbon nanotube hybrids

Tae Jin Yim, Juewen Liu, Yi Lu, Ravi S. Kane, Jonathan S. Dordick

Research output: Contribution to journalArticlepeer-review


We report herein the generation and characterization of DNAzyme-carbon nanotube conjugates. Biotinylated DNAzyme was attached to streptavidin-functionalized MWNTs. The resultant DNAzyme-MWNT conjugates exhibited Michaelis-Menten kinetics and multiple catalytic turnovers. The specific activity of the nanoscale conjugates was ∼1/3 of that for freely soluble DNAzyme. Such high activity may allow myriad applications ranging from the directed assembly of nanomaterials to nanoscale cellular therapeutics that rely on the RNA cleaving ability of DNAzymes.

Original languageEnglish (US)
Pages (from-to)12200-12201
Number of pages2
JournalJournal of the American Chemical Society
Issue number35
StatePublished - Sep 7 2005
Externally publishedYes

ASJC Scopus subject areas

  • Catalysis
  • General Chemistry
  • Biochemistry
  • Colloid and Surface Chemistry


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