Higher cardiorespiratory fitness levels are associated with greater hippocampal volume in breast cancer survivors

Laura Chaddock-Heyman, Michael J. Mackenzie, Krystle Zuniga, Gillian E. Cooke, Elizabeth Awick, Sarah Roberts, Kirk I. Erickson, Edward McAuley, Arthur F. Kramer

Research output: Contribution to journalArticle

Abstract

As breast cancer treatment is associated with declines in brain and cognitive health, it is important to identify strategies to enhance the cognitive vitality of cancer survivors. In particular, the hippocampus is known to play an important role in brain and memory declines following cancer treatment. The hippocampus is also known for its plasticity and positive association with cardiorespiratory fitness (CRF). The present study explores whether CRF may hold promise for lessening declines in brain and cognitive health of a sample of breast cancer survivors within 3 years of completion of primary cancer treatment. We explored the role of cardiovascular fitness in hippocampal structure in breast cancer survivors and non-cancer female controls, as well as performed a median split to compare differences in hippocampal volume in relatively higher fit and lower fit cancer survivors and non-cancer controls. Indeed, CRF and total hippocampal volume were positively correlated in the cancer survivors. In particular, higher fit breast cancer survivors had comparable hippocampal volumes to non-cancer control participants (Cohen’s d = 0.13, p > 0.3), whereas lower fit breast cancer survivors showed significantly smaller hippocampal volumes compared to both lower fit and higher fit control participants (Cohen’s d = 0.87, p < 0.05). These results are the first to identify that CRF may protect the brain health of breast cancer survivors within 3 years of treatment. The present study uniquely contributes to the field of cancer and cognition and emphasizes the importance of investigating how individual differences in CRF play a role in brain changes of breast cancer survivors.

Original languageEnglish (US)
Article number465
JournalFrontiers in Human Neuroscience
Volume9
Issue numberAUGUST
DOIs
StatePublished - Aug 26 2015

Fingerprint

Breast Neoplasms
Brain
Neoplasms
Hippocampus
Health
Cardiorespiratory Fitness
Individuality
Cognition

Keywords

  • Aerobic fitness
  • Brain
  • Cancer treatment
  • Memory
  • Physical activity

ASJC Scopus subject areas

  • Neuropsychology and Physiological Psychology
  • Neurology
  • Psychiatry and Mental health
  • Biological Psychiatry
  • Behavioral Neuroscience

Cite this

Chaddock-Heyman, L., Mackenzie, M. J., Zuniga, K., Cooke, G. E., Awick, E., Roberts, S., ... Kramer, A. F. (2015). Higher cardiorespiratory fitness levels are associated with greater hippocampal volume in breast cancer survivors. Frontiers in Human Neuroscience, 9(AUGUST), [465]. https://doi.org/10.3389/fnhum.2015.00465

Higher cardiorespiratory fitness levels are associated with greater hippocampal volume in breast cancer survivors. / Chaddock-Heyman, Laura; Mackenzie, Michael J.; Zuniga, Krystle; Cooke, Gillian E.; Awick, Elizabeth; Roberts, Sarah; Erickson, Kirk I.; McAuley, Edward; Kramer, Arthur F.

In: Frontiers in Human Neuroscience, Vol. 9, No. AUGUST, 465, 26.08.2015.

Research output: Contribution to journalArticle

Chaddock-Heyman, L, Mackenzie, MJ, Zuniga, K, Cooke, GE, Awick, E, Roberts, S, Erickson, KI, McAuley, E & Kramer, AF 2015, 'Higher cardiorespiratory fitness levels are associated with greater hippocampal volume in breast cancer survivors', Frontiers in Human Neuroscience, vol. 9, no. AUGUST, 465. https://doi.org/10.3389/fnhum.2015.00465
Chaddock-Heyman, Laura ; Mackenzie, Michael J. ; Zuniga, Krystle ; Cooke, Gillian E. ; Awick, Elizabeth ; Roberts, Sarah ; Erickson, Kirk I. ; McAuley, Edward ; Kramer, Arthur F. / Higher cardiorespiratory fitness levels are associated with greater hippocampal volume in breast cancer survivors. In: Frontiers in Human Neuroscience. 2015 ; Vol. 9, No. AUGUST.
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