High throughput cytotoxicity screening using photonic crystal biosensors

Leo L. Chan; Saujanya L. Gosangari; Kenneth L. Watkin; Brian T. Cunningham

doi:10.1109/SENSOR.2007.4300251

High throughput cytotoxicity screening using photonic crystal biosensors

Leo L. Chan, Saujanya L. Gosangari, Kenneth L. Watkin, Brian T. Cunningham

Research output: Chapter in Book/Report/Conference proceeding › Conference contribution

Abstract

A label-free method for detecting the attachment of human cancer cells to a biosensor surface for rapid screening for biological activity is described, in which attachment of a cell results in highly localized increase of the resonant reflected wavelength of a photonic crystal narrowband reflectance filter incorporated into a standard 96-well microplate. We demonstrate the efficacy of this method as an early screening technique for the rapid quantification of the rate of cancer cell proliferation on the sensor surface, and subsequently as a means for quantifying cell detachment resulting from apoptosis that is induced by exposure of the cells to cytotoxic chemicals.

Original language	English (US)
Title of host publication	TRANSDUCERS and EUROSENSORS '07 - 4th International Conference on Solid-State Sensors, Actuators and Microsystems
Pages	799-802
Number of pages	4
DOIs	https://doi.org/10.1109/SENSOR.2007.4300251
State	Published - Dec 1 2007
Event	4th International Conference on Solid-State Sensors, Actuators and Microsystems, TRANSDUCERS and EUROSENSORS '07 - Lyon, France Duration: Jun 10 2007 → Jun 14 2007

Publication series

Name	TRANSDUCERS and EUROSENSORS '07 - 4th International Conference on Solid-State Sensors, Actuators and Microsystems

Other

Other	4th International Conference on Solid-State Sensors, Actuators and Microsystems, TRANSDUCERS and EUROSENSORS '07
Country	France
City	Lyon
Period	6/10/07 → 6/14/07

Keywords

Apoptosis
Cell-based assay
Label-free
Microplate
Photonic crystal

ASJC Scopus subject areas

Control and Systems Engineering
Electrical and Electronic Engineering

Access to Document

10.1109/SENSOR.2007.4300251

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Cite this

Chan, L. L., Gosangari, S. L., Watkin, K. L., & Cunningham, B. T. (2007). High throughput cytotoxicity screening using photonic crystal biosensors. In TRANSDUCERS and EUROSENSORS '07 - 4th International Conference on Solid-State Sensors, Actuators and Microsystems (pp. 799-802). [4300251] (TRANSDUCERS and EUROSENSORS '07 - 4th International Conference on Solid-State Sensors, Actuators and Microsystems). https://doi.org/10.1109/SENSOR.2007.4300251

High throughput cytotoxicity screening using photonic crystal biosensors. / Chan, Leo L.; Gosangari, Saujanya L.; Watkin, Kenneth L.; Cunningham, Brian T.

TRANSDUCERS and EUROSENSORS '07 - 4th International Conference on Solid-State Sensors, Actuators and Microsystems. 2007. p. 799-802 4300251 (TRANSDUCERS and EUROSENSORS '07 - 4th International Conference on Solid-State Sensors, Actuators and Microsystems).

Research output: Chapter in Book/Report/Conference proceeding › Conference contribution

Chan, LL, Gosangari, SL, Watkin, KL & Cunningham, BT 2007, High throughput cytotoxicity screening using photonic crystal biosensors. in TRANSDUCERS and EUROSENSORS '07 - 4th International Conference on Solid-State Sensors, Actuators and Microsystems., 4300251, TRANSDUCERS and EUROSENSORS '07 - 4th International Conference on Solid-State Sensors, Actuators and Microsystems, pp. 799-802, 4th International Conference on Solid-State Sensors, Actuators and Microsystems, TRANSDUCERS and EUROSENSORS '07, Lyon, France, 6/10/07. https://doi.org/10.1109/SENSOR.2007.4300251

Chan LL, Gosangari SL, Watkin KL, Cunningham BT. High throughput cytotoxicity screening using photonic crystal biosensors. In TRANSDUCERS and EUROSENSORS '07 - 4th International Conference on Solid-State Sensors, Actuators and Microsystems. 2007. p. 799-802. 4300251. (TRANSDUCERS and EUROSENSORS '07 - 4th International Conference on Solid-State Sensors, Actuators and Microsystems). https://doi.org/10.1109/SENSOR.2007.4300251

Chan, Leo L. ; Gosangari, Saujanya L. ; Watkin, Kenneth L. ; Cunningham, Brian T. / High throughput cytotoxicity screening using photonic crystal biosensors. TRANSDUCERS and EUROSENSORS '07 - 4th International Conference on Solid-State Sensors, Actuators and Microsystems. 2007. pp. 799-802 (TRANSDUCERS and EUROSENSORS '07 - 4th International Conference on Solid-State Sensors, Actuators and Microsystems).

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