Abstract

Microarrays have found great utility to date. However, when considering recent reviews and speaking with leaders in the field applying microarrays daily to scientific problems, one quickly learns that current microarray methods are limited in terms of analytical methods. Key issues reside in the nondestructive determination of the amount and activity of the material on the microarray slide and measurement problems created by the use of labels. This chapter will provide an introduction to one type of label-free biosensor technology (the BIND system), show data from demonstration applications with this system, and describe the uses and limitations of BIND as currently configured for protein microarrays. In the final section, a description is provided of the future of the technology and practical improvements planned for near term commercial availability.

Original languageEnglish (US)
Title of host publicationFunctional Protein Microarrays in Drug Discovery
PublisherCRC Press
Pages217-236
Number of pages20
ISBN (Electronic)9781420009842
ISBN (Print)0849398096, 9780849398094
StatePublished - Jan 1 2007

ASJC Scopus subject areas

  • Medicine(all)
  • Biochemistry, Genetics and Molecular Biology(all)
  • Social Sciences(all)

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  • Cite this

    Laing, L. G., & Cunningham, B. (2007). High-resolution label- free detection applied to protein microarray research. In Functional Protein Microarrays in Drug Discovery (pp. 217-236). CRC Press.