Abstract
Microarrays have found great utility to date. However, when considering recent reviews and speaking with leaders in the field applying microarrays daily to scientific problems, one quickly learns that current microarray methods are limited in terms of analytical methods. Key issues reside in the nondestructive determination of the amount and activity of the material on the microarray slide and measurement problems created by the use of labels. This chapter will provide an introduction to one type of label-free biosensor technology (the BIND system), show data from demonstration applications with this system, and describe the uses and limitations of BIND as currently configured for protein microarrays. In the final section, a description is provided of the future of the technology and practical improvements planned for near term commercial availability.
| Original language | English (US) |
|---|---|
| Title of host publication | Functional Protein Microarrays in Drug Discovery |
| Publisher | CRC Press |
| Pages | 217-236 |
| Number of pages | 20 |
| ISBN (Electronic) | 9781420009842 |
| ISBN (Print) | 0849398096, 9780849398094 |
| State | Published - Jan 1 2007 |
ASJC Scopus subject areas
- General Medicine
- General Biochemistry, Genetics and Molecular Biology
- General Social Sciences