High resolution in-vivo intraarterial imaging with optical coherence tomography

Stephen A. Boppart, Costas Pitris, Ravi K. Ghanta, Xingde Li, Wolfgang Drexler, James G. Fujimoto, Mark E. Brezinski

Research output: Contribution to journalConference articlepeer-review


High resolution imaging of intraarterial structure is necessary for the identification of high risk coronary plaque. Optical Coherence Tomography (OCT), a recently developed technology, is a compact, fiber optic based imaging modality with resolutions between 2-20 μm and real time image acquisition rates. Previous in vitro studies have demonstrated the capability of OCT to identify plaque morphology and distinguish plaques with high lipid content. This work demonstrates the feasibility for OCT imaging of in-vivo intraarterial structures. We demonstrate the detection of microstructural detail and the effects of blood on imaging. Saline injections were required during imaging to reduce the signal attenuation of blood. An axial resolution of 10 μm was achieved. Microstructure within the arterial wall was sharply defined and correlated with histology. OCT shows potential to assist in the risk stratification of plaques and the guidance of interventional procedures, such as stent deployment.

Original languageEnglish (US)
Pages (from-to)324-327
Number of pages4
JournalProceedings of SPIE - The International Society for Optical Engineering
StatePublished - 1999
Externally publishedYes
EventProceedings of the 1999 Lasers in Surgery: Advanced Characterization, Therapeutics, and Systems IX - San Jose, CA, USA
Duration: Jan 23 1999Jan 24 1999

ASJC Scopus subject areas

  • Electronic, Optical and Magnetic Materials
  • Condensed Matter Physics
  • Computer Science Applications
  • Applied Mathematics
  • Electrical and Electronic Engineering


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