High resolution imaging of neoplastic lesions using optical coherence tomography

Costas Pitris, Annekathryn Goodman, Stephen A. Boppart, Wolfgang Drexler, Christine Jesser, Debra L. Stamper, Mark E. Brezinski, James G. Fujimoto

Research output: Contribution to journalConference article

Abstract

A technology capable of imaging tissue, at or near the cellular level, could lead to the detection of neoplasias at earlier stages than currently possible. This could significantly improve patient outcomes, since once cancer becomes metastatic, cure is difficult. Optical coherence tomography (OCT), a recently developed imaging technology, has been shown to achieve resolutions in the cellular and subcellular range (4-20 μm), and it could improve the diagnostic range of clinical imaging procedures. To assess the clinical applicability of OCT, neoplastic specimens from the urinary, gastrointestinal and female reproductive tract were imaged. Sharp differentiation of structures included the mucosa/submucosal/muscularis boundaries, epithelium, glands, supportive tissue, and intramural cysts. The ability of optical coherence tomography to image tissue microstructure at or near the cellular level make it a potentially powerful technology for minimally invasive assessment of tissue microstructure. The resolution of optical coherence tomography, which is greater than any current clinical imaging modality, make it particularly attractive for the assessment of early neoplastic changes.

Original languageEnglish (US)
Pages (from-to)79-85
Number of pages7
JournalProceedings of SPIE - The International Society for Optical Engineering
Volume3598
StatePublished - Jan 1 1999
Externally publishedYes
EventProceedings of the 1999 Coherence Domain Optical Methods in Biomedical Science and Clinical Applications III - San Jose, CA, USA
Duration: Jan 27 1999Jan 29 1999

ASJC Scopus subject areas

  • Electronic, Optical and Magnetic Materials
  • Condensed Matter Physics
  • Computer Science Applications
  • Applied Mathematics
  • Electrical and Electronic Engineering

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  • Cite this

    Pitris, C., Goodman, A., Boppart, S. A., Drexler, W., Jesser, C., Stamper, D. L., Brezinski, M. E., & Fujimoto, J. G. (1999). High resolution imaging of neoplastic lesions using optical coherence tomography. Proceedings of SPIE - The International Society for Optical Engineering, 3598, 79-85.