High-resolution Fourier-transform infrared chemical imaging with multiple synchrotron beams

Michael J. Nasse, Michael J. Walsh, Eric C. Mattson, Ruben Reininger, André Kajdacsy-Balla, Virgilia MacIas, Rohit Bhargava, Carol J. Hirschmugl

Research output: Contribution to journalArticlepeer-review


Conventional Fourier-transform infrared (FTIR) microspectroscopic systems are limited by an inevitable trade-off between spatial resolution, acquisition time, signal-to-noise ratio (SNR) and sample coverage. We present an FTIR imaging approach that substantially extends current capabilities by combining multiple synchrotron beams with wide-field detection. This advance allows truly diffraction-limited high-resolution imaging over the entire mid-infrared spectrum with high chemical sensitivity and fast acquisition speed while maintaining high-quality SNR.

Original languageEnglish (US)
Pages (from-to)413-416
Number of pages4
JournalNature Methods
Issue number5
StatePublished - May 2011

ASJC Scopus subject areas

  • Biotechnology
  • Biochemistry
  • Molecular Biology
  • Cell Biology


Dive into the research topics of 'High-resolution Fourier-transform infrared chemical imaging with multiple synchrotron beams'. Together they form a unique fingerprint.

Cite this