High-resolution cardiac MRI using partially separable functions and weighted spatial smoothness regularization

Anthony G. Christodoulou, Cornelius Brinegar, Justin P. Haldar, Haosen Zhang, Yi Jen L. Wu, Lesley M. Foley, T. Kevin Hitchens, Qing Ye, Chien Ho, Zhi Pei Liang

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Abstract

Imaging of cardiac morphology and functions in high spatiotemporal resolution using MRI is a challenging problem due to limited imaging speed and the inherent tradeoff between spatial resolution, temporal resolution, and signalto-noise ratio (SNR). The partially separable function (PSF) model has been shown to achieve high spatiotemporal resolution but can lead to noisy reconstructions. This paper proposes a method to improve the SNR and reduce artifacts in PSF-based reconstructions through the use of anatomical constraints. These anatomical constraints are obtained from a high-SNR image of composite (k, t)-space data (summed along the time axis) and used to regularize the PSF reconstruction. The method has been evaluated on experimental data of rat hearts to achieve 390 μm in-plane resolution and 15 ms temporal resolution.

Original languageEnglish (US)
Title of host publication2010 Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBC'10
Pages871-874
Number of pages4
DOIs
StatePublished - Dec 1 2010
Event2010 32nd Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBC'10 - Buenos Aires, Argentina
Duration: Aug 31 2010Sep 4 2010

Publication series

Name2010 Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBC'10

Other

Other2010 32nd Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBC'10
CountryArgentina
CityBuenos Aires
Period8/31/109/4/10

ASJC Scopus subject areas

  • Biomedical Engineering
  • Computer Vision and Pattern Recognition
  • Signal Processing
  • Health Informatics

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  • Cite this

    Christodoulou, A. G., Brinegar, C., Haldar, J. P., Zhang, H., Wu, Y. J. L., Foley, L. M., Hitchens, T. K., Ye, Q., Ho, C., & Liang, Z. P. (2010). High-resolution cardiac MRI using partially separable functions and weighted spatial smoothness regularization. In 2010 Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBC'10 (pp. 871-874). [5627889] (2010 Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBC'10). https://doi.org/10.1109/IEMBS.2010.5627889