High-Resolution 3D Spin-Echo MRSI Using Interleaved Water Navigators, Sparse Sampling and Subspace-Based Processing

Ruo Jing Ho, Fan Lam

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Abstract

This work presents a new method to achieve accelerated, high-resolution magnetic resonance spectroscopic imaging (MRSI) with spin-echo excitations. A new data acquisition strategy is proposed that integrates adiabatic refocusing, elimination of lipid suppression, rapid spatiospectral encoding with sparse (k,t)-space sampling, and interleaved water navigators. This integration leads to a significantly improved combination of volume coverage, spatial resolution (approximately 3 × 3.4 × 4 mm3) and speed (< 10 minutes), while eliminating additional scans for field mapping and coil sensitivity estimation. A data processing strategy that integrates parallel imaging reconstruction and subspace-based processing is devised to produce high-SNR spatiospectral reconstruction from the sparsely sampled, noisy and highresolution MRSI data. Promising in vivo results have been obtained to demonstrate the potential of the proposed method.Clinical relevance - The proposed method enabled volumetric MRSI with a nominal resolution of 3 × 3.4 × 4 mm3 in less than 10 minutes. With further developments and optimizations, the proposed method is expected to be useful for providing molecular-level information of brain functions and diseases, and has the potential to provide new biomarkers for disease diagnosis and treatment monitoring.

Original languageEnglish (US)
Title of host publication42nd Annual International Conferences of the IEEE Engineering in Medicine and Biology Society
Subtitle of host publicationEnabling Innovative Technologies for Global Healthcare, EMBC 2020
PublisherInstitute of Electrical and Electronics Engineers Inc.
Pages1465-1468
Number of pages4
ISBN (Electronic)9781728119908
DOIs
StatePublished - Jul 2020
Event42nd Annual International Conferences of the IEEE Engineering in Medicine and Biology Society, EMBC 2020 - Montreal, Canada
Duration: Jul 20 2020Jul 24 2020

Publication series

NameProceedings of the Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBS
Volume2020-July
ISSN (Print)1557-170X

Conference

Conference42nd Annual International Conferences of the IEEE Engineering in Medicine and Biology Society, EMBC 2020
CountryCanada
CityMontreal
Period7/20/207/24/20

ASJC Scopus subject areas

  • Signal Processing
  • Biomedical Engineering
  • Computer Vision and Pattern Recognition
  • Health Informatics

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