TY - JOUR
T1 - High-frequency Quantitative Ultrasound Imaging of Human Rotator Cuff Muscles
T2 - Assessment of Repeatability and Reproducibility
AU - Wu, Yuanshan
AU - Barrere, Victor
AU - Ashir, Aria
AU - Chen, Xiaojun
AU - Silva, Livia T.
AU - Jerban, Saeed
AU - Han, Aiguo
AU - Andre, Michael P.
AU - Shah, Sameer B.
AU - Chang, Eric Y.
N1 - The author(s) disclosed receipt of the following financial support for the research, authorship, and/or publication of this article: We gratefully acknowledge funding from the VA R&D service (I01CX001388, I01BX005952, and I01CX002118), NIH (R01AR075825 and K01AR080257), the Department of Defense (W81XWH-20-1-0927).
PY - 2024/1
Y1 - 2024/1
N2 - This study evaluated the repeatability and reproducibility of using high-frequency quantitative ultrasound (QUS) measurement of backscatter coefficient (BSC), grayscale analysis, and gray-level co-occurrence matrix (GLCM) textural analysis, to characterize human rotator cuff muscles. The effects of varying scanner settings across two different operators and two US systems were investigated in a healthy volunteer with normal rotator cuff muscles and a patient with chronic massive rotator cuff injury and substantial muscle degeneration. The results suggest that BSC is a promising method for assessing rotator cuff muscles in both control and pathological subjects, even when operators were free to adjust system settings (depth, level of focus, and time-gain compensation). Measurements were repeatable and reproducible across the different operators and ultrasound imaging platforms. In contrast, grayscale and GLCM analyses were found to be less reliable in this setting, with significant measurement variability. Overall, the repeatability and reproducibility measurements of BSC indicate its potential as a diagnostic tool for rotator cuff muscle evaluation.
AB - This study evaluated the repeatability and reproducibility of using high-frequency quantitative ultrasound (QUS) measurement of backscatter coefficient (BSC), grayscale analysis, and gray-level co-occurrence matrix (GLCM) textural analysis, to characterize human rotator cuff muscles. The effects of varying scanner settings across two different operators and two US systems were investigated in a healthy volunteer with normal rotator cuff muscles and a patient with chronic massive rotator cuff injury and substantial muscle degeneration. The results suggest that BSC is a promising method for assessing rotator cuff muscles in both control and pathological subjects, even when operators were free to adjust system settings (depth, level of focus, and time-gain compensation). Measurements were repeatable and reproducible across the different operators and ultrasound imaging platforms. In contrast, grayscale and GLCM analyses were found to be less reliable in this setting, with significant measurement variability. Overall, the repeatability and reproducibility measurements of BSC indicate its potential as a diagnostic tool for rotator cuff muscle evaluation.
KW - backscatter coefficient
KW - high frequency imaging
KW - quantitative imaging biomarkers alliance
KW - quantitative ultrasound
KW - rotator cuff muscles
KW - textural characterization
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U2 - 10.1177/01617346231207404
DO - 10.1177/01617346231207404
M3 - Article
C2 - 37981826
AN - SCOPUS:85177026001
SN - 0161-7346
VL - 46
SP - 56
EP - 70
JO - Ultrasonic Imaging
JF - Ultrasonic Imaging
IS - 1
ER -