High-definition fourier transform infrared spectroscopic imaging of breast tissue

L. Suzanne Leslie, Andre Kadjacsy-Balla, Rohit Bhargava

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Abstract

Breast cancer diagnosis relies on staining serial sections of a biopsy in a process that can be time intensive and costly. Fourier transform infrared imaging (FT-IR) is a non-destructive, label-free chemical imaging technique that uses the vibrational structure of the biological molecules of the sample to provide contrast for images at any absorption peak in the mid-infrared. The full potential of spectroscopic imaging has been limited by the spatial resolution provided by most commercial instruments. By increasing the magnification and numerical aperture of the microscope, image pixel sizes on the order of 1.1 micron can be achieved, allowing HD FT-IR spectroscopic imaging to provide high quality images that could aid in histopathology, diagnosis, and studies of breast cancer progression.

Original languageEnglish (US)
Title of host publicationMedical Imaging 2015
Subtitle of host publicationDigital Pathology
EditorsMetin N. Gurcan, Anant Madabhushi
PublisherSPIE
ISBN (Electronic)9781628415100
DOIs
StatePublished - Jan 1 2015
EventMedical Imaging 2015: Digital Pathology - Orlando, United States
Duration: Feb 25 2015Feb 26 2015

Publication series

NameProgress in Biomedical Optics and Imaging - Proceedings of SPIE
Volume9420
ISSN (Print)1605-7422

Other

OtherMedical Imaging 2015: Digital Pathology
CountryUnited States
CityOrlando
Period2/25/152/26/15

Keywords

  • Breast
  • FT-IR
  • High definition
  • Magnification
  • Numerical aperture
  • Resolution
  • SNR
  • Spectroscopic imaging

ASJC Scopus subject areas

  • Electronic, Optical and Magnetic Materials
  • Biomaterials
  • Atomic and Molecular Physics, and Optics
  • Radiology Nuclear Medicine and imaging

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  • Cite this

    Suzanne Leslie, L., Kadjacsy-Balla, A., & Bhargava, R. (2015). High-definition fourier transform infrared spectroscopic imaging of breast tissue. In M. N. Gurcan, & A. Madabhushi (Eds.), Medical Imaging 2015: Digital Pathology [94200I] (Progress in Biomedical Optics and Imaging - Proceedings of SPIE; Vol. 9420). SPIE. https://doi.org/10.1117/12.2082461