TY - GEN
T1 - Hierarchical modeling of alternative exon usage associations with survival
AU - Sadeque, Ahmed
AU - Serão, Nicola V.L.
AU - Southey, Bruce R.
AU - Fazal, Zeeshan
AU - Rodriguez-Zas, Sandra L.
PY - 2011
Y1 - 2011
N2 - Exon expression platforms have allowed the detection of associations between alternative exon usage (AEU) and the proliferation of malignant cells in cancer. However, due to inadequate number of studies performed on AEU and the approaches utilized to detect AEU events, well established biomarkers for GBM are not available. The expression of exons corresponding to 25,403 genes was related to the survival of 328 patients diagnosed with Glioblastoma multiforme (GBM). An approach that takes exon expression into account was adopted to detect the association between exon expression and survival. Association between expression and survival were identified in 22 single-exon genes 248 genes with 2-25 exons, 1430 genes with >24 and <50 exons and 215 genes with >50 exons. Among the multiple-exon genes exhibiting AEU were epidermal growth factor (EGF) and nidogen2 (NID2) that have known association with GBM. These results are consistent with reports that these genes have 12 and 10 transcripts, respectively.
AB - Exon expression platforms have allowed the detection of associations between alternative exon usage (AEU) and the proliferation of malignant cells in cancer. However, due to inadequate number of studies performed on AEU and the approaches utilized to detect AEU events, well established biomarkers for GBM are not available. The expression of exons corresponding to 25,403 genes was related to the survival of 328 patients diagnosed with Glioblastoma multiforme (GBM). An approach that takes exon expression into account was adopted to detect the association between exon expression and survival. Association between expression and survival were identified in 22 single-exon genes 248 genes with 2-25 exons, 1430 genes with >24 and <50 exons and 215 genes with >50 exons. Among the multiple-exon genes exhibiting AEU were epidermal growth factor (EGF) and nidogen2 (NID2) that have known association with GBM. These results are consistent with reports that these genes have 12 and 10 transcripts, respectively.
KW - Alternative Exon Usage
KW - Glioblastoma Multiforme
KW - Hierarchical Model
KW - Robust Multichip Average
KW - Tukey biweight
UR - http://www.scopus.com/inward/record.url?scp=84856007236&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84856007236&partnerID=8YFLogxK
U2 - 10.1109/BIBMW.2011.6112528
DO - 10.1109/BIBMW.2011.6112528
M3 - Conference contribution
AN - SCOPUS:84856007236
SN - 9781457716133
T3 - 2011 IEEE International Conference on Bioinformatics and Biomedicine Workshops, BIBMW 2011
SP - 978
EP - 980
BT - 2011 IEEE International Conference on Bioinformatics and Biomedicine Workshops, BIBMW 2011
T2 - 2011 IEEE International Conference onBioinformatics and Biomedicine Workshops, BIBMW 2011
Y2 - 12 November 2011 through 15 November 2011
ER -