Heterologous production of the lantibiotic ala(0)actagardine in escherichia coli

Yanxiang Shi, Alejandro Bueno, Wilfred A. Vander Donk

Research output: Contribution to journalArticlepeer-review

Abstract

We report the heterologous production of Ala(0)actagardine in E. coli by co-expression of the substrate peptide GarA and its modification enzymes GarM and GarO. The activity of GarO, a luciferase-like monooxygenase that introduces the unique sulfoxide group of actagardine, was also investigated in vitro.

Original languageEnglish (US)
Pages (from-to)10966-10968
Number of pages3
JournalChemical Communications
Volume48
Issue number89
DOIs
StatePublished - Oct 15 2012

ASJC Scopus subject areas

  • Catalysis
  • Electronic, Optical and Magnetic Materials
  • Ceramics and Composites
  • Chemistry(all)
  • Surfaces, Coatings and Films
  • Metals and Alloys
  • Materials Chemistry

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