Heterogeneous nucleants for crystallogenesis and bioseparation

Umang V. Shah, Christian Amberg, Ying Diao, Zhongqiang Yang, Jerry Y.Y. Heng

Research output: Contribution to journalReview articlepeer-review


Crystallisation is a widely used separation step for both isolation and purification of products, for a wide range of chemical processes. Nevertheless, there remains a great challenge in controlling the onset of crystallisation - nucleation. Heterogeneous nucleation has been investigated over the last three decades to determine physico-chemical relationships between nucleant and solute properties, which may be key for controlling nucleation. This can lead to rational design of nucleants facilitating selective crystallisation of particles with desired properties. In this opinion, a review on recent advances in developing mechanistic understanding of the role of interfacial properties, mainly nano-scale surface topography, surface chemistry and the combination of both features, in controlling nucleation is presented. An outlook for the development of next generation nucleants and the potential application areas are presented.

Original languageEnglish (US)
Article number238
Pages (from-to)69-75
Number of pages7
JournalCurrent Opinion in Chemical Engineering
StatePublished - May 2015

ASJC Scopus subject areas

  • General Energy


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