TY - JOUR
T1 - Herpesvirus and calicivirus infection in a black-footed cat (Felis nigripes) family group following vaccination
AU - Rivas, Anne E.
AU - Langan, Jennifer N.
AU - Colegrove, Kathleen M.
AU - Terio, Karen
AU - Adkesson, Michael J.
N1 - Publisher Copyright:
Copyright 2015 by American Association of Zoo Veterinarians.
PY - 2015/3/1
Y1 - 2015/3/1
N2 - Preventive healthcare recommendations for zoo felids include vaccination against primary viral diseases that affect domestic felids. Although associated with a more-substantial immune response in their domestic counterparts, use of modified live virus vaccines (MLV) in nondomestic carnivores can result in vaccine-induced viral disease. This case report details a feline herpesvirus and calicivirus outbreak in two black-footed cat (Felis nigripes) kittens and their dam following use of an MLV in the kittens. Clinical signs included anorexia, nasal discharge, sneezing, and tachypnea. Patient history, clinical signs, real-time polymerase chain reaction results, and histopathologic evaluation of tissues confirmed the diagnosis. Although unable to definitively prove that the disease observed in these cases was caused by the MLV, there is strong temporal and circumstantial evidence that this was the case. This outbreak of feline upper respiratory infection following vaccination with a multivalent MLV resulted in significant morbidity and mortality, serving as an important reminder that recombinant or killed vaccines are the safest choice for use in nondomestic species, particularly in kittens.
AB - Preventive healthcare recommendations for zoo felids include vaccination against primary viral diseases that affect domestic felids. Although associated with a more-substantial immune response in their domestic counterparts, use of modified live virus vaccines (MLV) in nondomestic carnivores can result in vaccine-induced viral disease. This case report details a feline herpesvirus and calicivirus outbreak in two black-footed cat (Felis nigripes) kittens and their dam following use of an MLV in the kittens. Clinical signs included anorexia, nasal discharge, sneezing, and tachypnea. Patient history, clinical signs, real-time polymerase chain reaction results, and histopathologic evaluation of tissues confirmed the diagnosis. Although unable to definitively prove that the disease observed in these cases was caused by the MLV, there is strong temporal and circumstantial evidence that this was the case. This outbreak of feline upper respiratory infection following vaccination with a multivalent MLV resulted in significant morbidity and mortality, serving as an important reminder that recombinant or killed vaccines are the safest choice for use in nondomestic species, particularly in kittens.
KW - Black-footed cat
KW - Feline calicivirus
KW - Feline herpesvirus
KW - Felis nigripes
KW - Modified live virus vaccine
KW - Vaccine induced
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U2 - 10.1638/2013-0216R1.1
DO - 10.1638/2013-0216R1.1
M3 - Article
C2 - 25831588
AN - SCOPUS:84924935613
SN - 1042-7260
VL - 46
SP - 141
EP - 145
JO - Journal of Zoo and Wildlife Medicine
JF - Journal of Zoo and Wildlife Medicine
IS - 1
ER -