Abstract
Purpose. We determined whether naturally-occurring lenticular myopia in English Springer spaniels (ESS) has a genetic component. Methods. Streak retinoscopy was performed on 226 related ESS 30 minutes after the onset of pharmacologic mydriasis and cycloplegia. A pedigree was constructed to determine relationships between affected offspring and parents. Estimation of heritability was done in a Bayesian analysis (facilitated by the MCMCglmm package of R) of refractive error in a model, including terms for sex and coat color. Myopia was defined as ≤-0.5 diopters (D) spherical equivalent. Results. The median refractive error for ESS was 0.25 D (range, -3.5 to +4.5 D). Median age was 0.2 years (range, 0.1-15 years). The prevalence of myopia in related ESS was 19% (42/226). The ESS had a strong correlation (r = 0.95) for refractive error between the two eyes. Moderate heritability was present for refractive error with a mean value of 0.29 (95% highest probability density, 0.07-0.50). Conclusions. The distribution of refractive error, and subsequently lenticular myopia, has a moderate genetic component in ESS. Further investigation of genes responsible for regulation of the development of refractive ocular components in canines is warranted.
Original language | English (US) |
---|---|
Pages (from-to) | 7324-7328 |
Number of pages | 5 |
Journal | Investigative Ophthalmology and Visual Science |
Volume | 54 |
Issue number | 12 |
DOIs | |
State | Published - Sep 26 2013 |
Externally published | Yes |
Keywords
- English Springer spaniel
- Heritability
- Lenticular myopia
- Refractive error
ASJC Scopus subject areas
- Ophthalmology
- Sensory Systems
- Cellular and Molecular Neuroscience