Abstract
We report the histological findings in a case of hereditary diabetes insipidus (HDI) using vasopressin (VP) immunohistochemistry. The hypothalamus displayed a marked loss of magnocellular VP neurons, with preservation of the smaller cells. The neurohypophysis was severely atrophic with scanty immunoreactivity. Our results support the hypothesis that HDI results from a selective degeneration of VP neurons affecting chiefly the magnocellular elements projecting to the neurohypophysis. The sparing of the parvocellular component may reflect the projection of these neurons to non-pituitary targets.
Original language | English (US) |
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Pages (from-to) | 345-348 |
Number of pages | 4 |
Journal | Acta Neuropathologica |
Volume | 81 |
Issue number | 3 |
DOIs | |
State | Published - Feb 1991 |
Externally published | Yes |
Keywords
- Hereditary diabetes insipidus
- Hypothalamus
- Neurohypophysis
- Vasopressin
ASJC Scopus subject areas
- Pathology and Forensic Medicine
- Clinical Neurology
- Cellular and Molecular Neuroscience