Hereditary diabetes insipidus: an immunohistochemical study of the hypothalamus and pituitary gland

C. Bergeron, K. Kovacs, C. Ezrin, C. Mizzen

Research output: Contribution to journalArticlepeer-review

Abstract

We report the histological findings in a case of hereditary diabetes insipidus (HDI) using vasopressin (VP) immunohistochemistry. The hypothalamus displayed a marked loss of magnocellular VP neurons, with preservation of the smaller cells. The neurohypophysis was severely atrophic with scanty immunoreactivity. Our results support the hypothesis that HDI results from a selective degeneration of VP neurons affecting chiefly the magnocellular elements projecting to the neurohypophysis. The sparing of the parvocellular component may reflect the projection of these neurons to non-pituitary targets.

Original languageEnglish (US)
Pages (from-to)345-348
Number of pages4
JournalActa Neuropathologica
Volume81
Issue number3
DOIs
StatePublished - Feb 1 1991

Keywords

  • Hereditary diabetes insipidus
  • Hypothalamus
  • Neurohypophysis
  • Vasopressin

ASJC Scopus subject areas

  • Pathology and Forensic Medicine
  • Clinical Neurology
  • Cellular and Molecular Neuroscience

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