Hepatoprotective and a Potential Antiviral Effect of Biphenyl Dimethyl Dicarboxylate/Amantadine for and Acute Viral Hepatitis Induced by MHV-2 in ICR Mice

Soo Joo Seong; Hyouk Jun Chin; Tae Joon Won; Kwang Woo Hwang; Do Ik Lee

Hepatoprotective and a Potential Antiviral Effect of Biphenyl Dimethyl Dicarboxylate/Amantadine for and Acute Viral Hepatitis Induced by MHV-2 in ICR Mice

Soo Joo Seong, Hyouk Jun Chin, Tae Joon Won, Kwang Woo Hwang, Do Ik Lee

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Abstract

The mouse hepatitis virus (MHV-2) induces broad collapses, focal necrosis and cytolysis of hepatocytes, and leads to death after three to five days of intraperitoneal injection in mice. The present study investigated whether the combinatorial treatment of dimethyl dicarboxylate/amantadine (2:1) showed hepatoprotective and/or antiviral properties in MHV-2 infected ICR mice. In the study, we found that dimethyl dicarboxylate/amantadine group (VDDBA) increased the survival rate (30.8%) when compared to positive control, VL (7.7%) and that VDDBA lengthened the survival time (4.2d)after MHV-2 infection. In addition, ALT and AST were well regulated when treated with VDDBA (p

Original language	Korean
Pages (from-to)	194-198
Number of pages	5
Journal	YAKHAK HOEJI
Volume	51
Issue number	3
State	Published - Jun 2007
Externally published	Yes

Keywords

MHV-2
lamivudine
ICR mouse
HBV
amantadine
dimethyl dicarboxylate

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title = "Hepatoprotective and a Potential Antiviral Effect of Biphenyl Dimethyl Dicarboxylate/Amantadine for and Acute Viral Hepatitis Induced by MHV-2 in ICR Mice",

abstract = "The mouse hepatitis virus (MHV-2) induces broad collapses, focal necrosis and cytolysis of hepatocytes, and leads to death after three to five days of intraperitoneal injection in mice. The present study investigated whether the combinatorial treatment of dimethyl dicarboxylate/amantadine (2:1) showed hepatoprotective and/or antiviral properties in MHV-2 infected ICR mice. In the study, we found that dimethyl dicarboxylate/amantadine group (VDDBA) increased the survival rate (30.8%) when compared to positive control, VL (7.7%) and that VDDBA lengthened the survival time (4.2d)after MHV-2 infection. In addition, ALT and AST were well regulated when treated with VDDBA (p",

keywords = "MHV-2, lamivudine, ICR mouse, HBV, amantadine, dimethyl dicarboxylate",

author = "Seong, {Soo Joo} and Chin, {Hyouk Jun} and Won, {Tae Joon} and Hwang, {Kwang Woo} and Lee, {Do Ik}",

year = "2007",

month = jun,

language = "Korean",

volume = "51",

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journal = "YAKHAK HOEJI",

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publisher = "The Pharmaceutical Society of Korea",

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T1 - Hepatoprotective and a Potential Antiviral Effect of Biphenyl Dimethyl Dicarboxylate/Amantadine for and Acute Viral Hepatitis Induced by MHV-2 in ICR Mice

AU - Seong, Soo Joo

AU - Chin, Hyouk Jun

AU - Won, Tae Joon

AU - Hwang, Kwang Woo

AU - Lee, Do Ik

PY - 2007/6

Y1 - 2007/6

N2 - The mouse hepatitis virus (MHV-2) induces broad collapses, focal necrosis and cytolysis of hepatocytes, and leads to death after three to five days of intraperitoneal injection in mice. The present study investigated whether the combinatorial treatment of dimethyl dicarboxylate/amantadine (2:1) showed hepatoprotective and/or antiviral properties in MHV-2 infected ICR mice. In the study, we found that dimethyl dicarboxylate/amantadine group (VDDBA) increased the survival rate (30.8%) when compared to positive control, VL (7.7%) and that VDDBA lengthened the survival time (4.2d)after MHV-2 infection. In addition, ALT and AST were well regulated when treated with VDDBA (p

AB - The mouse hepatitis virus (MHV-2) induces broad collapses, focal necrosis and cytolysis of hepatocytes, and leads to death after three to five days of intraperitoneal injection in mice. The present study investigated whether the combinatorial treatment of dimethyl dicarboxylate/amantadine (2:1) showed hepatoprotective and/or antiviral properties in MHV-2 infected ICR mice. In the study, we found that dimethyl dicarboxylate/amantadine group (VDDBA) increased the survival rate (30.8%) when compared to positive control, VL (7.7%) and that VDDBA lengthened the survival time (4.2d)after MHV-2 infection. In addition, ALT and AST were well regulated when treated with VDDBA (p

KW - MHV-2

KW - lamivudine

KW - ICR mouse

KW - HBV

KW - amantadine

KW - dimethyl dicarboxylate

M3 - Article

SN - 0377-9556

VL - 51

SP - 194

EP - 198

JO - YAKHAK HOEJI

JF - YAKHAK HOEJI

IS - 3

ER -