Hepatoprotective and a Potential Antiviral Effect of Biphenyl Dimethyl Dicarboxylate/Amantadine for and Acute Viral Hepatitis Induced by MHV-2 in ICR Mice

Soo Joo Seong, Hyouk Jun Chin, Tae Joon Won, Kwang Woo Hwang, Do Ik Lee

Research output: Contribution to journalArticlepeer-review


The mouse hepatitis virus (MHV-2) induces broad collapses, focal necrosis and cytolysis of hepatocytes, and leads to death after three to five days of intraperitoneal injection in mice. The present study investigated whether the combinatorial treatment of dimethyl dicarboxylate/amantadine (2:1) showed hepatoprotective and/or antiviral properties in MHV-2 infected ICR mice. In the study, we found that dimethyl dicarboxylate/amantadine group (VDDBA) increased the survival rate (30.8%) when compared to positive control, VL (7.7%) and that VDDBA lengthened the survival time (4.2d)after MHV-2 infection. In addition, ALT and AST were well regulated when treated with VDDBA (p
Original languageKorean
Pages (from-to)194-198
Number of pages5
Issue number3
StatePublished - Jun 2007
Externally publishedYes


  • MHV-2
  • lamivudine
  • ICR mouse
  • HBV
  • amantadine
  • dimethyl dicarboxylate

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