Hemispheric specialization in human dorsal frontal cortex and medial temporal lobe for verbal and nonverbal memory encoding

William M. Kelley, Francis M. Miezin, Kathleen B. McDermott, Randy L. Buckner, Marcus E. Raichle, Neal J. Cohen, John M. Ollinger, Erbil Akbudak, Thomas E. Conturo, Abraham Z. Snyder, Steven E. Petersen

Research output: Contribution to journalArticle

Abstract

The involvement of dorsal frontal and medial temporal regions during the encoding of words, namable line-drawn objects, and unfamiliar faces was examined using functional magnetic resonance imaging (fMRI). Robust dorsal frontal activations were observed in each instance, but lateralization was strongly dependent on the materials being encoded. Encoding of words produced left-lateralized dorsal frontal activation, whereas encoding of unfamiliar faces produced homologous right-lateralized activation. Encoding of namable objects, which are amenable to both verbal and nonverbal encoding, yielded bilateral dorsal frontal activation. A similar pattern of results was observed in the medial temporal lobe. These results indicate that regions in both hemispheres underlie human long-term memory encoding, and these regions can be engaged differentially according to the nature of the material being encoded.

Original languageEnglish (US)
Pages (from-to)927-936
Number of pages10
JournalNeuron
Volume20
Issue number5
DOIs
StatePublished - May 1998

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Cerebral Dominance
Frontal Lobe
Temporal Lobe
Long-Term Memory
Magnetic Resonance Imaging

ASJC Scopus subject areas

  • Neuroscience(all)

Cite this

Kelley, W. M., Miezin, F. M., McDermott, K. B., Buckner, R. L., Raichle, M. E., Cohen, N. J., ... Petersen, S. E. (1998). Hemispheric specialization in human dorsal frontal cortex and medial temporal lobe for verbal and nonverbal memory encoding. Neuron, 20(5), 927-936. https://doi.org/10.1016/S0896-6273(00)80474-2

Hemispheric specialization in human dorsal frontal cortex and medial temporal lobe for verbal and nonverbal memory encoding. / Kelley, William M.; Miezin, Francis M.; McDermott, Kathleen B.; Buckner, Randy L.; Raichle, Marcus E.; Cohen, Neal J.; Ollinger, John M.; Akbudak, Erbil; Conturo, Thomas E.; Snyder, Abraham Z.; Petersen, Steven E.

In: Neuron, Vol. 20, No. 5, 05.1998, p. 927-936.

Research output: Contribution to journalArticle

Kelley, WM, Miezin, FM, McDermott, KB, Buckner, RL, Raichle, ME, Cohen, NJ, Ollinger, JM, Akbudak, E, Conturo, TE, Snyder, AZ & Petersen, SE 1998, 'Hemispheric specialization in human dorsal frontal cortex and medial temporal lobe for verbal and nonverbal memory encoding', Neuron, vol. 20, no. 5, pp. 927-936. https://doi.org/10.1016/S0896-6273(00)80474-2
Kelley, William M. ; Miezin, Francis M. ; McDermott, Kathleen B. ; Buckner, Randy L. ; Raichle, Marcus E. ; Cohen, Neal J. ; Ollinger, John M. ; Akbudak, Erbil ; Conturo, Thomas E. ; Snyder, Abraham Z. ; Petersen, Steven E. / Hemispheric specialization in human dorsal frontal cortex and medial temporal lobe for verbal and nonverbal memory encoding. In: Neuron. 1998 ; Vol. 20, No. 5. pp. 927-936.
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