TY - JOUR
T1 - Hematological toxicity and therapeutic efficacy of lomustine in 20 tumor-bearing cats
T2 - Critical assessment of a practical dosing regimen
AU - Fan, Timothy M.
AU - Kitchell, Barbara E.
AU - Dhaliwal, Ravinder S.
AU - Jones, Pamela D.
AU - Hintermeister, John G.
AU - Paria, Biman C.
PY - 2002
Y1 - 2002
N2 - Twenty cats with spontaneously arising tumors received oral lomustine at a dose range of 32 to 59 mg/m2 every 21 days. Due to biohazard concerns associated with lomustine capsule reformulation, a standardized 1O-mg capsule dosage was used for all cats regardless of body weight. Severe hematological toxicity was infrequent, with the incidence of either grade III or IV neutropenia and thrombocytopenia being 4.1 % and 1.0%, respectively. Cats receiving higher cumulative doses of lomustine trended toward a greater likelihood for progressive neutropenia (P=0.07). Two cats with lymphoma, two cats with fibrosarcoma, and one cat with multiple myeloma achieved a measurable partial response to lomustine therapy. Cats treated with higher dosages of lomustine trended toward statistically significant higher response rates (P=0.07).
AB - Twenty cats with spontaneously arising tumors received oral lomustine at a dose range of 32 to 59 mg/m2 every 21 days. Due to biohazard concerns associated with lomustine capsule reformulation, a standardized 1O-mg capsule dosage was used for all cats regardless of body weight. Severe hematological toxicity was infrequent, with the incidence of either grade III or IV neutropenia and thrombocytopenia being 4.1 % and 1.0%, respectively. Cats receiving higher cumulative doses of lomustine trended toward a greater likelihood for progressive neutropenia (P=0.07). Two cats with lymphoma, two cats with fibrosarcoma, and one cat with multiple myeloma achieved a measurable partial response to lomustine therapy. Cats treated with higher dosages of lomustine trended toward statistically significant higher response rates (P=0.07).
UR - http://www.scopus.com/inward/record.url?scp=0036064182&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0036064182&partnerID=8YFLogxK
U2 - 10.5326/0380357
DO - 10.5326/0380357
M3 - Article
C2 - 12118689
AN - SCOPUS:0036064182
SN - 0587-2871
VL - 38
SP - 357
EP - 363
JO - Journal of the American Animal Hospital Association
JF - Journal of the American Animal Hospital Association
IS - 4
ER -