Helicobacter pylori VacA, a paradigm for toxin multifunctionality

Timothy L. Cover, Steven Robert Blanke

Research output: Contribution to journalReview article

Abstract

Bacterial protein toxins alter eukaryotic cellular processes and enable bacteria to successfully colonize their hosts. In recent years, there has been increased recognition that many bacterial toxins are multifunctional proteins that can have pleiotropic effects on mammalian cells and tissues. In this review, we examine a multifunctional toxin (VacA) that is produced by the bacterium Helicobacter pylori. The actions of H. pylori VacA represent a paradigm for how bacterial secreted toxins contribute to colonization and virulence in multiple ways.

Original languageEnglish (US)
Pages (from-to)320-332
Number of pages13
JournalNature Reviews Microbiology
Volume3
Issue number4
DOIs
StatePublished - Apr 1 2005

ASJC Scopus subject areas

  • Microbiology
  • Immunology and Microbiology(all)
  • Infectious Diseases

Fingerprint Dive into the research topics of 'Helicobacter pylori VacA, a paradigm for toxin multifunctionality'. Together they form a unique fingerprint.

  • Cite this