Helicobacter pylori activation of PARP-1 usurping a versatile regulator of host cellular health

Carlos W. Nossa, Steven R. Blanke

Research output: Contribution to journalArticlepeer-review

Abstract

Chronic infection of the human stomach by Helicobacter pylori is an important risk factor for gastric cancer. H. pylori produces a cache of virulence factors that promote colonization and persistence, which, in turn, contributes to a robust inflammatory response at the host-pathogen interface. Recently, we reported that H. pylori activates the abundant nuclear regulator poly(ADPribose) polymerase (PARP)-1, resulting in the production of the catabolite poly(ADP-ribose) (PAR). PARP-1 is emerging as a key player in establishing homeostasis at the host-pathogen interface. In this article, we summarize the discovery of H. pylori-dependent PARP-1 activation, and discuss potential roles for PARP-1 in H. pylori-mediated gastric disease. In light of the remarkable successes that have reported for treating inflammatory disorders and cancers with PARP-1 inhibitors, we discuss the prospects of targeting PARP-1 for treatment of H. pylori-associated gastric disease.

Original languageEnglish (US)
JournalGut Microbes
Volume1
Issue number6
DOIs
StatePublished - Nov 2010

Keywords

  • Activation
  • Apoptosis
  • Cancer
  • Helicobacter pylori
  • Inflammation
  • PARP-1

ASJC Scopus subject areas

  • Microbiology
  • Gastroenterology
  • Microbiology (medical)
  • Infectious Diseases

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