Abstract
Chronic infection of the human stomach by Helicobacter pylori is an important risk factor for gastric cancer. H. pylori produces a cache of virulence factors that promote colonization and persistence, which, in turn, contributes to a robust inflammatory response at the host-pathogen interface. Recently, we reported that H. pylori activates the abundant nuclear regulator poly(ADPribose) polymerase (PARP)-1, resulting in the production of the catabolite poly(ADP-ribose) (PAR). PARP-1 is emerging as a key player in establishing homeostasis at the host-pathogen interface. In this article, we summarize the discovery of H. pylori-dependent PARP-1 activation, and discuss potential roles for PARP-1 in H. pylori-mediated gastric disease. In light of the remarkable successes that have reported for treating inflammatory disorders and cancers with PARP-1 inhibitors, we discuss the prospects of targeting PARP-1 for treatment of H. pylori-associated gastric disease.
Original language | English (US) |
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Journal | Gut Microbes |
Volume | 1 |
Issue number | 6 |
DOIs | |
State | Published - Nov 2010 |
Keywords
- Activation
- Apoptosis
- Cancer
- Helicobacter pylori
- Inflammation
- PARP-1
ASJC Scopus subject areas
- Microbiology
- Gastroenterology
- Microbiology (medical)
- Infectious Diseases