Helical poly(arginine) mimics with superior cell-penetrating and molecular transporting properties

Haoyu Tang, Lichen Yin, Kyung Hoon Kim, Jianjun Cheng

Research output: Contribution to journalArticlepeer-review

Abstract

Poly(arginine) mimics bearing long hydrophobic side chains adopt a stable helical conformation and exhibit helix-related cell-penetrating properties. Elongating the polypeptide backbone length and increasing side chain hydrophobicity further increase the helicities of poly(arginine) mimics. These helical poly(arginine) mimics show superior cell membrane permeability up to two orders of magnitude higher than that of HIV-TAT peptide and excellent DNA and siRNA delivery efficiencies in various mammalian cells.

Original languageEnglish (US)
Pages (from-to)3839-3844
Number of pages6
JournalChemical Science
Volume4
Issue number10
DOIs
StatePublished - Aug 26 2013

ASJC Scopus subject areas

  • Chemistry(all)

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