Heart rate variability and cardiovascular disease in people with spinal cord injury

Fuyuan Liao, Yih Kuen Jan

Research output: Chapter in Book/Report/Conference proceedingChapter


Spinal cord injury (SCI) disrupts the descending spinal autonomic pathways, resulting in dysfunctions of the cardiovascular system and other organs. The alterations in autonomic cardiovascular control, combined with paralysis-associated physical inactivity, predispose people with SCI to a high incidence of cardiovascular disease (CVD). Recent research findings indicate that CVD is a leading cause of morbidity and mortality in people with SCI. It is clinically important to early detect people with SCI at risk for CVD. Heart rate variability (HRV) provides a means for quantifying residual sympathovagal regulation of the heart and may be a promising biomarker for assessing risk of CVD. This chapter reviews CVD in people with SCI, describes methods to quantify linear and nonlinear HRV, and discuss the potential role of HRV in assessing risk of CVD in people with SCI.

Original languageEnglish (US)
Title of host publicationHeart Rate Variability (HRV)
Subtitle of host publicationPrognostic Significance, Risk Factors and Clinical Applications
EditorsShelby Walters
PublisherNova Science Publishers, Inc.
Number of pages15
ISBN (Electronic)9781634637725
ISBN (Print)9781634637367
StatePublished - Jan 1 2015

ASJC Scopus subject areas

  • General Medicine


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