Health and nutrition beyond essential nutrients: The evolution of the bioactives concept for human health

John W. Erdman

doi:10.1016/j.mam.2022.101116

Health and nutrition beyond essential nutrients: The evolution of the bioactives concept for human health

Research output: Contribution to journal › Review article › peer-review

Abstract

Our food supply contains a range of essential and non-essential food components. There are substantial epidemiologic findings and additional clinical data to support the health benefits for some non-essential food components – these compounds are often referred to as bioactives. While there is a well-established process in place to make science-based dietary recommendations for essential nutrients, this is not the case for bioactive food components. This manuscript reviews the evolution of the RDAs and the transition to a DRI framework for establishing requirements for essential nutrients. Then, the potential of development of public health recommendations for bioactives will be explored and the benefits and challenges of making recommendations will be presented. The scientific support for case studies for lutein and flavan-3-ols, will be made. Finally, suggestions for frameworks that might be considered by authoritative policy-making bodies when evaluating the efficacy and safely of proposed bioactives will be discussed.

Original language	English (US)
Article number	101116
Journal	Molecular Aspects of Medicine
Volume	89
DOIs	https://doi.org/10.1016/j.mam.2022.101116
State	Published - Feb 2023

Keywords

Bioactives
Dietary Reference Intakes (DRIs)
Flavan-3-ols
Lutein
Recommended Dietary Intakes (RDAs)

ASJC Scopus subject areas

Molecular Medicine
Molecular Biology
Biochemistry
Clinical Biochemistry

Online availability

10.1016/j.mam.2022.101116

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title = "Health and nutrition beyond essential nutrients: The evolution of the bioactives concept for human health",

abstract = "Our food supply contains a range of essential and non-essential food components. There are substantial epidemiologic findings and additional clinical data to support the health benefits for some non-essential food components – these compounds are often referred to as bioactives. While there is a well-established process in place to make science-based dietary recommendations for essential nutrients, this is not the case for bioactive food components. This manuscript reviews the evolution of the RDAs and the transition to a DRI framework for establishing requirements for essential nutrients. Then, the potential of development of public health recommendations for bioactives will be explored and the benefits and challenges of making recommendations will be presented. The scientific support for case studies for lutein and flavan-3-ols, will be made. Finally, suggestions for frameworks that might be considered by authoritative policy-making bodies when evaluating the efficacy and safely of proposed bioactives will be discussed.",

keywords = "Bioactives, Dietary Reference Intakes (DRIs), Flavan-3-ols, Lutein, Recommended Dietary Intakes (RDAs)",

author = "Erdman, {John W.}",

note = "Funding Information: Dr. Erdman is Professor Emeritus at the University of Illinois. He holds grant funding from NIH, Abbott Nutrition through the Center for Nutrition, Learning and Memory at the University of Illinois and the Cancer Center at Illinois. He is a scientific advisor to the Soy Nutrition Institute-Global and is a member of the Board of Trustees for the Institute of Food and Nutrition Science (IFANS). He has previously consulted for Mars Inc. Publisher Copyright: {\textcopyright} 2022 Elsevier Ltd",

year = "2023",

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doi = "10.1016/j.mam.2022.101116",

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journal = "Molecular Aspects of Medicine",

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AU - Erdman, John W.

N1 - Funding Information: Dr. Erdman is Professor Emeritus at the University of Illinois. He holds grant funding from NIH, Abbott Nutrition through the Center for Nutrition, Learning and Memory at the University of Illinois and the Cancer Center at Illinois. He is a scientific advisor to the Soy Nutrition Institute-Global and is a member of the Board of Trustees for the Institute of Food and Nutrition Science (IFANS). He has previously consulted for Mars Inc. Publisher Copyright: © 2022 Elsevier Ltd

PY - 2023/2

Y1 - 2023/2

N2 - Our food supply contains a range of essential and non-essential food components. There are substantial epidemiologic findings and additional clinical data to support the health benefits for some non-essential food components – these compounds are often referred to as bioactives. While there is a well-established process in place to make science-based dietary recommendations for essential nutrients, this is not the case for bioactive food components. This manuscript reviews the evolution of the RDAs and the transition to a DRI framework for establishing requirements for essential nutrients. Then, the potential of development of public health recommendations for bioactives will be explored and the benefits and challenges of making recommendations will be presented. The scientific support for case studies for lutein and flavan-3-ols, will be made. Finally, suggestions for frameworks that might be considered by authoritative policy-making bodies when evaluating the efficacy and safely of proposed bioactives will be discussed.

AB - Our food supply contains a range of essential and non-essential food components. There are substantial epidemiologic findings and additional clinical data to support the health benefits for some non-essential food components – these compounds are often referred to as bioactives. While there is a well-established process in place to make science-based dietary recommendations for essential nutrients, this is not the case for bioactive food components. This manuscript reviews the evolution of the RDAs and the transition to a DRI framework for establishing requirements for essential nutrients. Then, the potential of development of public health recommendations for bioactives will be explored and the benefits and challenges of making recommendations will be presented. The scientific support for case studies for lutein and flavan-3-ols, will be made. Finally, suggestions for frameworks that might be considered by authoritative policy-making bodies when evaluating the efficacy and safely of proposed bioactives will be discussed.

KW - Bioactives

KW - Dietary Reference Intakes (DRIs)

KW - Flavan-3-ols

KW - Lutein

KW - Recommended Dietary Intakes (RDAs)

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Health and nutrition beyond essential nutrients: The evolution of the bioactives concept for human health

Abstract

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