Harmonically decoupled gradient light interference microscopy (HD-GLIM)

Yi Wang, Mikhail E. Kandel, Michael J. Fanous, Chenfei Hu, Hsuan Yu Chen, Xiaoxu Lu, Gabriel Popescu

Research output: Contribution to journalArticlepeer-review


Differential phase sensitive methods, such as Nomarski microscopy, play an important role in quantitative phase imaging due to their compatibility with partially coherent illumination and excellent optical sectioning ability. In this Letter, we propose a new system, to the best of our knowledge, to retrieve differential phase information from transparent samples. It is based on a 4f optical system with an amplitude-type spatial light modulator (SLM), which removes the need for traditional differential interference contrast (DIC) optics and specialized phase-only SLMs. We demonstrate the principle of harmonically decoupled gradient light interference microscopy using standard samples, as well as static and dynamic biospecimens.

Original languageEnglish (US)
Pages (from-to)1487-1490
Number of pages4
JournalOptics Letters
Issue number6
StatePublished - Mar 15 2020

ASJC Scopus subject areas

  • Atomic and Molecular Physics, and Optics


Dive into the research topics of 'Harmonically decoupled gradient light interference microscopy (HD-GLIM)'. Together they form a unique fingerprint.

Cite this