Abstract
Peripheral afferent lymph was obtained by cannulation of a collecting vessel in 17 healthy men (mean age 26 years). Lymph/plasma ratios of all vitamin K-dependent factors were lower than expected from molecular weight. Factor VII, factor IX and tissue factor pathway inhibitor (TFPI) lymph/plasma activity ratios were higher than antigen ratios. Activated factor VII (FVIIa) and TFPI-Xa complex concentrations were higher in lymph than plasma, and the raised FVIIa did not appear to be due to cannulation. The fibrinogen lymph/plasma activity (Clauss) ratio averaged about 20% of the antigen ratio. The result of an ELISA for D-dimer was higher in lymph than plasma, often more than five-fold. This high level in lymph was not explored but may indicate proteolysis of fibrinogen and fibrin with release of D-like and D-dimer-like fragments in interstitial fluid.
Original language | English (US) |
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Pages (from-to) | 427-432 |
Number of pages | 6 |
Journal | Thrombosis and Haemostasis |
Volume | 83 |
Issue number | 3 |
DOIs | |
State | Published - 2000 |
Externally published | Yes |
Keywords
- D-dimer
- Haemostatic factors
- Peripheral lymph
ASJC Scopus subject areas
- Hematology