Haem-oxygen reactive intermediates: Catalysis by the two-step

T. M. Makris, I. G. Denisov, S. G. Sligar

Research output: Contribution to journalArticlepeer-review


The catalytic schemes of a variety of haem enzymes, including the P450 mono-oxygenases, consist of a number of common reactive haem-oxygen adducts. The characterization of these intermediates by optical and EPR spectroscopies has reinforced the similarity of these intermediate states in a number of haem enzyme systems. Furthermore, the reactivity of these states in P450 and horseradish peroxidase, in which multiple potent oxidants are formed, provides a paradigm for many other haem enzymes.

Original languageEnglish (US)
Pages (from-to)516-519
Number of pages4
JournalBiochemical Society transactions
Issue number3
StatePublished - Jun 2003


  • Dioxygen activation
  • P450 mechanism

ASJC Scopus subject areas

  • Biochemistry


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