Gut Microbiome of Coexisting BaAka Pygmies and Bantu Reflects Gradients of Traditional Subsistence Patterns

Andres Gomez, Klara J. Petrzelkova, Michael B. Burns, Carl J. Yeoman, Katherine R. Amato, Klara Vlckova, David Modry, Angelique Todd, Carolyn A. Jost Robinson, Melissa J. Remis, Manolito G. Torralba, Elise Morton, Juan D. Umaña, Franck Carbonero, H. Rex Gaskins, Karen E. Nelson, Brenda A. Wilson, Rebecca M. Stumpf, Bryan A. White, Steven R. LeighRan Blekhman

Research output: Contribution to journalArticle

Abstract

To understand how the gut microbiome is impacted by human adaptation to varying environments, we explored gut bacterial communities in the BaAka rainforest hunter-gatherers and their agriculturalist Bantu neighbors in the Central African Republic. Although the microbiome of both groups is compositionally similar, hunter-gatherers harbor increased abundance of Prevotellaceae, Treponema, and Clostridiaceae, while the Bantu gut microbiome is dominated by Firmicutes. Comparisons with US Americans reveal microbiome differences between Africans and westerners but show western-like features in the Bantu, including an increased abundance of predictive carbohydrate and xenobiotic metabolic pathways. In contrast, the hunter-gatherer gut shows increased abundance of predicted virulence, amino acid, and vitamin metabolism functions, as well as dominance of lipid and amino-acid-derived metabolites, as determined through metabolomics. Our results demonstrate gradients of traditional subsistence patterns in two neighboring African groups and highlight the adaptability of the microbiome in response to host ecology.

Original languageEnglish (US)
Pages (from-to)2142-2153
Number of pages12
JournalCell Reports
Volume14
Issue number9
DOIs
StatePublished - Mar 8 2016

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Microbiota
Amino Acids
Xenobiotics
Ecology
Metabolites
Ports and harbors
Central African Republic
Metabolism
Treponema
Vitamins
Metabolomics
Carbohydrates
Metabolic Networks and Pathways
Lipids
Virulence
Gastrointestinal Microbiome

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)

Cite this

Gomez, A., Petrzelkova, K. J., Burns, M. B., Yeoman, C. J., Amato, K. R., Vlckova, K., ... Blekhman, R. (2016). Gut Microbiome of Coexisting BaAka Pygmies and Bantu Reflects Gradients of Traditional Subsistence Patterns. Cell Reports, 14(9), 2142-2153. https://doi.org/10.1016/j.celrep.2016.02.013

Gut Microbiome of Coexisting BaAka Pygmies and Bantu Reflects Gradients of Traditional Subsistence Patterns. / Gomez, Andres; Petrzelkova, Klara J.; Burns, Michael B.; Yeoman, Carl J.; Amato, Katherine R.; Vlckova, Klara; Modry, David; Todd, Angelique; Jost Robinson, Carolyn A.; Remis, Melissa J.; Torralba, Manolito G.; Morton, Elise; Umaña, Juan D.; Carbonero, Franck; Gaskins, H. Rex; Nelson, Karen E.; Wilson, Brenda A.; Stumpf, Rebecca M.; White, Bryan A.; Leigh, Steven R.; Blekhman, Ran.

In: Cell Reports, Vol. 14, No. 9, 08.03.2016, p. 2142-2153.

Research output: Contribution to journalArticle

Gomez, A, Petrzelkova, KJ, Burns, MB, Yeoman, CJ, Amato, KR, Vlckova, K, Modry, D, Todd, A, Jost Robinson, CA, Remis, MJ, Torralba, MG, Morton, E, Umaña, JD, Carbonero, F, Gaskins, HR, Nelson, KE, Wilson, BA, Stumpf, RM, White, BA, Leigh, SR & Blekhman, R 2016, 'Gut Microbiome of Coexisting BaAka Pygmies and Bantu Reflects Gradients of Traditional Subsistence Patterns', Cell Reports, vol. 14, no. 9, pp. 2142-2153. https://doi.org/10.1016/j.celrep.2016.02.013
Gomez, Andres ; Petrzelkova, Klara J. ; Burns, Michael B. ; Yeoman, Carl J. ; Amato, Katherine R. ; Vlckova, Klara ; Modry, David ; Todd, Angelique ; Jost Robinson, Carolyn A. ; Remis, Melissa J. ; Torralba, Manolito G. ; Morton, Elise ; Umaña, Juan D. ; Carbonero, Franck ; Gaskins, H. Rex ; Nelson, Karen E. ; Wilson, Brenda A. ; Stumpf, Rebecca M. ; White, Bryan A. ; Leigh, Steven R. ; Blekhman, Ran. / Gut Microbiome of Coexisting BaAka Pygmies and Bantu Reflects Gradients of Traditional Subsistence Patterns. In: Cell Reports. 2016 ; Vol. 14, No. 9. pp. 2142-2153.
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