Gut Microbial Carbohydrate Metabolism Hinders Weight Loss in Overweight Adults Undergoing Lifestyle Intervention With a Volumetric Diet

David A. Muñiz Pedrogo, Michael D. Jensen, Carol T. Van Dyke, Joseph A. Murray, Jeffrey A Woods, Jun Chen, Purna C. Kashyap, Vandana Nehra

Research output: Contribution to journalArticle

Abstract

The rising incidence of obesity requires the reevaluation of our current therapeutic strategies to optimize patient outcomes. The objective of this study was to determine whether compositional and functional characteristics of the gut microbiota in adults predict responses to a comprehensive lifestyle intervention program in overweight and obese adults. We recruited 26 participants from the Mayo Clinic Obesity Treatment Research Program between August 6, 2013, and September 12, 2013, to participate in a lifestyle intervention program for weight loss. Adults aged 18 to 65 years with a body mass index of 27 to 39.9 kg/m 2 and able to provide informed consent were included in the study. Fecal stool samples were obtained at baseline and after 3 months. Loss of at least 5% of baseline weight after 3 months was defined as success. Clinical characteristics and gut microbial composition and function were compared between those who achieved at least 5% and those who achieved less than 5% weight loss. After 3 months, 9 of 26 participants lost at least 5% of their weight. The mean weight loss was 7.89 kg (95% CI, 6.46-9.32 kg) in the success group and 1.51 kg (95% CI, 0.52-2.49 kg) in the less than 5% weight loss group. An increased abundance of Phascolarctobacterium was associated with success. In contrast, an increased abundance of Dialister and of genes encoding gut microbial carbohydrate-active enzymes was associated with failure to lose 5% body weight. A gut microbiota with increased capability for carbohydrate metabolism appears to be associated with decreased weight loss in overweight and obese patients undergoing a lifestyle intervention program.

Original languageEnglish (US)
Pages (from-to)1104-1110
Number of pages7
JournalMayo Clinic Proceedings
Volume93
Issue number8
DOIs
StatePublished - Aug 1 2018

Fingerprint

Carbohydrate Metabolism
Life Style
Weight Loss
Diet
Obesity
Weight Reduction Programs
Weights and Measures
Informed Consent
Body Mass Index
Body Weight
Carbohydrates
Incidence
Enzymes
Therapeutics
Research
Genes
Gastrointestinal Microbiome

ASJC Scopus subject areas

  • Medicine(all)

Cite this

Gut Microbial Carbohydrate Metabolism Hinders Weight Loss in Overweight Adults Undergoing Lifestyle Intervention With a Volumetric Diet. / Muñiz Pedrogo, David A.; Jensen, Michael D.; Van Dyke, Carol T.; Murray, Joseph A.; Woods, Jeffrey A; Chen, Jun; Kashyap, Purna C.; Nehra, Vandana.

In: Mayo Clinic Proceedings, Vol. 93, No. 8, 01.08.2018, p. 1104-1110.

Research output: Contribution to journalArticle

Muñiz Pedrogo, David A. ; Jensen, Michael D. ; Van Dyke, Carol T. ; Murray, Joseph A. ; Woods, Jeffrey A ; Chen, Jun ; Kashyap, Purna C. ; Nehra, Vandana. / Gut Microbial Carbohydrate Metabolism Hinders Weight Loss in Overweight Adults Undergoing Lifestyle Intervention With a Volumetric Diet. In: Mayo Clinic Proceedings. 2018 ; Vol. 93, No. 8. pp. 1104-1110.
@article{2b78c299e48b442f9aca8b2f5be4378a,
title = "Gut Microbial Carbohydrate Metabolism Hinders Weight Loss in Overweight Adults Undergoing Lifestyle Intervention With a Volumetric Diet",
abstract = "The rising incidence of obesity requires the reevaluation of our current therapeutic strategies to optimize patient outcomes. The objective of this study was to determine whether compositional and functional characteristics of the gut microbiota in adults predict responses to a comprehensive lifestyle intervention program in overweight and obese adults. We recruited 26 participants from the Mayo Clinic Obesity Treatment Research Program between August 6, 2013, and September 12, 2013, to participate in a lifestyle intervention program for weight loss. Adults aged 18 to 65 years with a body mass index of 27 to 39.9 kg/m 2 and able to provide informed consent were included in the study. Fecal stool samples were obtained at baseline and after 3 months. Loss of at least 5{\%} of baseline weight after 3 months was defined as success. Clinical characteristics and gut microbial composition and function were compared between those who achieved at least 5{\%} and those who achieved less than 5{\%} weight loss. After 3 months, 9 of 26 participants lost at least 5{\%} of their weight. The mean weight loss was 7.89 kg (95{\%} CI, 6.46-9.32 kg) in the success group and 1.51 kg (95{\%} CI, 0.52-2.49 kg) in the less than 5{\%} weight loss group. An increased abundance of Phascolarctobacterium was associated with success. In contrast, an increased abundance of Dialister and of genes encoding gut microbial carbohydrate-active enzymes was associated with failure to lose 5{\%} body weight. A gut microbiota with increased capability for carbohydrate metabolism appears to be associated with decreased weight loss in overweight and obese patients undergoing a lifestyle intervention program.",
author = "{Mu{\~n}iz Pedrogo}, {David A.} and Jensen, {Michael D.} and {Van Dyke}, {Carol T.} and Murray, {Joseph A.} and Woods, {Jeffrey A} and Jun Chen and Kashyap, {Purna C.} and Vandana Nehra",
year = "2018",
month = "8",
day = "1",
doi = "10.1016/j.mayocp.2018.02.019",
language = "English (US)",
volume = "93",
pages = "1104--1110",
journal = "Mayo Clinic Proceedings",
issn = "0025-6196",
publisher = "Elsevier Science",
number = "8",

}

TY - JOUR

T1 - Gut Microbial Carbohydrate Metabolism Hinders Weight Loss in Overweight Adults Undergoing Lifestyle Intervention With a Volumetric Diet

AU - Muñiz Pedrogo, David A.

AU - Jensen, Michael D.

AU - Van Dyke, Carol T.

AU - Murray, Joseph A.

AU - Woods, Jeffrey A

AU - Chen, Jun

AU - Kashyap, Purna C.

AU - Nehra, Vandana

PY - 2018/8/1

Y1 - 2018/8/1

N2 - The rising incidence of obesity requires the reevaluation of our current therapeutic strategies to optimize patient outcomes. The objective of this study was to determine whether compositional and functional characteristics of the gut microbiota in adults predict responses to a comprehensive lifestyle intervention program in overweight and obese adults. We recruited 26 participants from the Mayo Clinic Obesity Treatment Research Program between August 6, 2013, and September 12, 2013, to participate in a lifestyle intervention program for weight loss. Adults aged 18 to 65 years with a body mass index of 27 to 39.9 kg/m 2 and able to provide informed consent were included in the study. Fecal stool samples were obtained at baseline and after 3 months. Loss of at least 5% of baseline weight after 3 months was defined as success. Clinical characteristics and gut microbial composition and function were compared between those who achieved at least 5% and those who achieved less than 5% weight loss. After 3 months, 9 of 26 participants lost at least 5% of their weight. The mean weight loss was 7.89 kg (95% CI, 6.46-9.32 kg) in the success group and 1.51 kg (95% CI, 0.52-2.49 kg) in the less than 5% weight loss group. An increased abundance of Phascolarctobacterium was associated with success. In contrast, an increased abundance of Dialister and of genes encoding gut microbial carbohydrate-active enzymes was associated with failure to lose 5% body weight. A gut microbiota with increased capability for carbohydrate metabolism appears to be associated with decreased weight loss in overweight and obese patients undergoing a lifestyle intervention program.

AB - The rising incidence of obesity requires the reevaluation of our current therapeutic strategies to optimize patient outcomes. The objective of this study was to determine whether compositional and functional characteristics of the gut microbiota in adults predict responses to a comprehensive lifestyle intervention program in overweight and obese adults. We recruited 26 participants from the Mayo Clinic Obesity Treatment Research Program between August 6, 2013, and September 12, 2013, to participate in a lifestyle intervention program for weight loss. Adults aged 18 to 65 years with a body mass index of 27 to 39.9 kg/m 2 and able to provide informed consent were included in the study. Fecal stool samples were obtained at baseline and after 3 months. Loss of at least 5% of baseline weight after 3 months was defined as success. Clinical characteristics and gut microbial composition and function were compared between those who achieved at least 5% and those who achieved less than 5% weight loss. After 3 months, 9 of 26 participants lost at least 5% of their weight. The mean weight loss was 7.89 kg (95% CI, 6.46-9.32 kg) in the success group and 1.51 kg (95% CI, 0.52-2.49 kg) in the less than 5% weight loss group. An increased abundance of Phascolarctobacterium was associated with success. In contrast, an increased abundance of Dialister and of genes encoding gut microbial carbohydrate-active enzymes was associated with failure to lose 5% body weight. A gut microbiota with increased capability for carbohydrate metabolism appears to be associated with decreased weight loss in overweight and obese patients undergoing a lifestyle intervention program.

UR - http://www.scopus.com/inward/record.url?scp=85050350771&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=85050350771&partnerID=8YFLogxK

U2 - 10.1016/j.mayocp.2018.02.019

DO - 10.1016/j.mayocp.2018.02.019

M3 - Article

VL - 93

SP - 1104

EP - 1110

JO - Mayo Clinic Proceedings

JF - Mayo Clinic Proceedings

SN - 0025-6196

IS - 8

ER -